Cancers, Vol. 13, Pages 4567: Liver Stiffness-Based Risk Prediction Model for Hepatocellular Carcinoma in Patients with Nonalcoholic Fatty Liver Disease
Cancers, Vol. 13, Pages 4567: Liver Stiffness-Based Risk Prediction Model for Hepatocellular Carcinoma in Patients with Nonalcoholic Fatty Liver Disease
Cancers doi: 10.3390/cancers13184567
Authors:
Jae Seung Lee
Dong Hyun Sinn
Soo Young Park
Hye Jung Shin
Hye Won Lee
Beom Kyung Kim
Jun Yong Park
Do Young Kim
Sang Hoon Ahn
Joo Hyun Oh
Jung Il Lee
Seung Up Kim
Non-alcoholic fatty liver disease (NAFLD) is associated with an increased hepatocellular carcinoma (HCC) risk. We established and validated a liver stiffness (LS)-based risk prediction model for HCC development in patients with NAFLD. A total of 2666 and 467 patients with NAFLD were recruited in the training and validation cohorts, respectively. NAFLD was defined as controlled attenuated parameter ≥238 dB/m by transient elastography. Over a median of 64.6 months, HCC developed in 22 (0.8%) subjects in the training cohort. Subjects who developed HCC were older and had higher prevalence of diabetes and cirrhosis, lower platelet count, and higher AST levels compared to those who did not develop HCC (all p < 0.05). In multivariate analysis, age ≥60 years (hazard ratio (HR) = 9.1), platelet count <150 × 103/μL (HR = 3.7), and LS ≥9.3 kPa (HR = 13.8) were independent predictors (all p < 0.05) that were used to develop a risk prediction model for HCC development, together with AST ≥34 IU/L. AUCs for predicting HCC development at 2, 3, and 5 years were 0.94...
Source: Cancers - Category: Cancer & Oncology Authors: Jae Seung Lee Dong Hyun Sinn Soo Young Park Hye Jung Shin Hye Won Lee Beom Kyung Kim Jun Yong Park Do Young Kim Sang Hoon Ahn Joo Hyun Oh Jung Il Lee Seung Up Kim Tags: Article Source Type: research
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