An updated classification and mechanistic insights into ligand binding of the substrate ‐binding proteins

In this study, the list of SBPs belonging to different clusters was updated (764 SBPs) compared to the previously reported study (504 SBPs). Furthermore, a new cluster referred to as cluster H was identified. Results reveal that SBPs follow different ligand-binding mechanisms. Intriguingly, the majority of the SBPs follow the ‘one domain movement’ rather than the well-known ‘Venus Fly-trap’ mechanism. Moreover, SBPs of a few clusters display subdomain conformational movement rather than the complete movement of the N- and C-terminal domains.

Source: FEBS Letters - August 20, 2021 Category: Biochemistry Authors: Monika Chandravanshi, Sisir Kant Tripathi, Shankar Prasad Kanaujia Tags: Communication Source Type: research