Identifying FDA-approved drugs with multimodal properties against COVID-19 using a data-driven approach and a lung organoid model of SARS-CoV-2 entry

CONCLUSIONS: Small clinical studies reported that general statin use, and specifically, atorvastatin use, are associated with protective effects against COVID-19. Our study corroborrates these findings and supports the investigation of atorvastatin in larger clinical studies. Ultimately, our framework demonstrates one promising way to fast-track the identification of compounds for COVID-19, which could similarly be applied when tackling future pandemics.PMID:34503440 | DOI:10.1186/s10020-021-00356-6

Source: Molecular Medicine - September 10, 2021 Category: Molecular Biology Authors: Rodrigo R R Duarte Dennis C Copertino Luis P I ñiguez Jez L Marston Yaron Bram Yuling Han Robert E Schwartz Shuibing Chen Douglas F Nixon Timothy R Powell Source Type: research