EU recommends Roche’s Avastin plus chemotherapy to treat cervical cancer

The European Union's (EU) Committee for Medicinal Products for Human Use (CHMP) has recommended the use of Avastin (bevacizumab) in combination with standard chemotherapy (paclitaxel and cisplatin or paclitaxel and topotecan in patients who cannot re…
Source: Pharmaceutical Technology - Category: Pharmaceuticals Source Type: news

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Peng-Hui Wang Radical hysterectomy (RH) is the standard treatment for early stage cervical cancer, but the surgical approach for locally bulky-size cervical cancer (LBS-CC) is still unclear. We retrospectively compared the outcomes of women with LBS-CC treated with neoadjuvant chemotherapy (NACT) and subsequent RH between the robotic (R-RH) and abdominal approaches (A-RH). Between 2012 and 2014, 39 women with LBS-CC FIGO (International Federation of Gynecology and Obstetrics) stage IB2–IIB were treated with NACT-R-RH (n = 18) or NACT-A-RH (n = 21). Surgical parameters and prognosis were compared. Patient ch...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
Abstract The dosage of cisplatin is adjusted according to creatinine clearance (Ccr) estimated by the Cockcroft-Gault formula, which is commonly used as a marker for renal function. It is known that different serum creatinine (Scr) levels are reported depending on the analytical methods utilized such as the Scr level by the enzyme method being lower than that by the Jaffe method. Although the enzyme method is used in Japan, most drug dosages, including cisplatin, are adjusted according to the estimated Ccr using the Jaffe method-based Scr level. The purpose of this study was to investigate whether assessment of re...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - Category: Drugs & Pharmacology Authors: Tags: Yakugaku Zasshi Source Type: research
ConclusionAlthough LM arising from gynecological cancers is considered rare, identification of LM may be important to predict prognosis and develop new therapeutic strategies.
Source: International Journal of Clinical Oncology - Category: Cancer & Oncology Source Type: research
ConclusionsThe study met is primary endpoint with 86% of non-progressive disease at  + 12 months, reduced pain and better functional status. CA in the hands of expert interventional radiologists, should be considered in guidelines as a reasonable treatment option for these pts. CA will soon challenge medical therapy as front-line therapy in the forthcoming randomized trial CRYO DESMO-02.Clinical trial identificationNCT02476305.Legal entity responsible for the studyH ôpitaux Universitaires de Strasbourg.FundingFrench National Cancer Institute (INCa).DisclosureJ. Kurtz: Travel / Accommodation / Expenses: ...
Source: Annals of Oncology - Category: Cancer & Oncology Source Type: research
CONCLUSIONS: Chemo-brachytherapy is associated with higher acute toxicity with comparable response rates. Small patient numbers and short follow up impedes us from providing conclusive evidence. PMID: 31554360 [PubMed - in process]
Source: Asian Pacific Journal of Cancer Prevention - Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research
Immunotherapy could replace chemotherapy in some patients with recurrent/metastatic cervical and vaginal or vulvar cancers.
Source: CancerNetwork - Category: Cancer & Oncology Authors: Source Type: news
[allAfrica] Johannesburg -The government of Senegal will begin to offer free breast or cervical cancer chemotherapy in public hospitals from October 2019, reports the BBC.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
Publication date: Available online 18 September 2019Source: Journal of Trace Elements in Medicine and BiologyAuthor(s): Chun Jiang, Qing-Qing Zhao, Qian Gao, Shao-Bin Wu, Guo Wang, Xiao-Ping Chen, Lin Wang, Ying-Ying Zhang, Jie TangAbstractBackground and AimMajor and trace elements play an important role in human body, and it has been reported that ionomic distribution differ greatly in tumor patients. The aim of the present study was to investigate the effects of cisplatin-based neoadjuvant chemoradiotherapy on the ionomic profile in human plasma as a potential biomarker for the therapeutic effects of cervical cancer.Meth...
Source: Journal of Trace Elements in Medicine and Biology - Category: Biochemistry Source Type: research
This study aimed to evaluate the prognostic value of combining pretreatment Epstein ‐Barr virus (EBV) DNA level and cervical node necrosis (CNN) for patients with nasopharyngeal carcinoma (NPC) receiving intensity‐modulated radiotherapy (IMRT). A total of 607 incident nonmetastatic NPC patients treated with IMRT ± chemotherapy were reviewed. Patients were divided into four g roups based on EBV DNA level and CNN status. The primary endpoint was progression‐free survival (PFS). Kaplan‐Meier curves with log‐rank test were applied to compare survival outcomes and the Cox proportional model was used t...
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
CONCLUSIONS: According to our analysis, NSRH surgery after NAC via balloon occluded arterial infusion brings beneficial results to patients with bulky IB2 to IIB cervical cancers. PMID: 31497250 [PubMed]
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
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