Gonyautoxins 2/3 Local Periarticular Injection for Pain Management after Total Knee Arthroplasty: A Double-Blind, Randomized Study

J Knee Surg DOI: 10.1055/s-0041-1735312The purpose of this study was to compare the efficacy of periarticular infiltration of gonyautoxin 2/3 (GTX 2/3) and a mixture of levobupivacaine, ketorolac, and epinephrine for pain management after total knee arthroplasty (TKA). Forty-eight patients were randomly allocated to receive periarticular infiltration of 40 µg GTX 2/3 (n = 24) diluted in 30 mL of sodium chloride 0.9% (study group) or a combination of 300 mg of levobupivacaine, 1 mg of epinephrine, and 60 mg ketorolac (n = 24) diluted in 150 mL of sodium chloride 0.9% (control group). Intraoperative anesthetic and surgical techniques were identical for both groups. Postoperatively, all patients received patient-controlled analgesia (morphine bolus of 1 mg; lockout interval of 8 minutes), acetaminophen, and ketoprofen for 72 hours. A blinded investigator recorded morphine consumption, which was the primary outcome. Also, the range of motion (ROM) and static and dynamic pain were assessed at 6, 12, 36, and 60 hours after surgery. The incidence of adverse events, time to readiness for discharge, and length of hospital stay were also recorded. The median of total cumulative morphine consumption was 16 mg (range, 0–62 mg) in the GTX 2/3 group and 9 mg (range, 0–54 mg) in control group, which did not reach statistical difference (median test, p&thin...
Source: Journal of Knee Surgery - Category: Orthopaedics Authors: Tags: Original Article Source Type: research

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Source: Journal of Anesthesia - Category: Anesthesiology Source Type: research
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Source: Journal of Knee Surgery - Category: Orthopaedics Authors: Tags: Original Article Source Type: research
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Source: Anesthesiology - Category: Anesthesiology Source Type: research
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Source: Journal of Opioid Management - Category: Addiction Authors: Source Type: research
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Source: Annales de Cardiologie et d'Angeiologie - Category: Cardiology Authors: Source Type: research
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Source: Journal of Opioid Management - Category: Addiction Authors: Source Type: research
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Source: Minimally Invasive Therapy and Allied Technologies - Category: Surgery Authors: Source Type: research
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