Comparison of the impact of allelic polymorphisms in PfAMA1 on the induction of T Cell responses in high and low malaria endemic communities in Ghana

Malaria eradication requires a combined effort involving all available control tools, and these efforts would be complemented by an effective vaccine. The antigen targets of immune responses may show polymorph...
Source: Malaria Journal - Category: Infectious Diseases Authors: Tags: Research Source Type: research

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deu Daniel-Ribeiro Josué da Costa Lima-Junior The Plasmodium vivax Cysteine-Rich Protective Antigen (PvCyRPA) has an important role in erythrocyte invasion and has been considered a target for vivax malaria vaccine development. Nonetheless, its genetic diversity remains uncharted in Brazilian malaria-endemic areas. Therefore, we investigated the pvcyrpa genetic polymorphism in 98 field isolates from the Brazilian Amazon and its impact on the antigenicity of predicted B-cell epitopes. Genetic diversity parameters, population genetic analysis, neutrality test and the median-joining network were analyzed, and the...
Source: Genes - Category: Genetics & Stem Cells Authors: Tags: Article Source Type: research
Adv Exp Med Biol. 2021;1313:273-291. doi: 10.1007/978-3-030-67452-6_12.ABSTRACTMalaria is a pandemic with nearly half of global population at risk, caused by parasite Plasmodium species, particularly P. falciparum with a high morbidity and mortality, especially among children. There is an urgent need for development of population protective vaccines, such as in sub-Saharan low-income countries, where P. falciparum malaria is endemic. After years of endeavour with children and adults for safety and efficacy clinical trials, the P. falciparum circumsporozoite protein antigen, is targeted by specific antibodies induced by rec...
Source: Advances in Experimental Medicine and Biology - Category: Research Authors: Source Type: research
Am J Trop Med Hyg. 2021 Oct 11:tpmd210369. doi: 10.4269/ajtmh.21-0369. Online ahead of print.ABSTRACTThe RTS,S/AS01 malaria vaccine confers only moderate protection against malaria. Evidence suggests that the effectiveness of the RTS,S/AS01 vaccine depends upon the parasite population genetics, specifically regarding the circumsporozoite protein haplotypes in the population. We investigated Plasmodium falciparum circumsporozoite protein (PfCSP) gene sequences from two endemic sites in 2018 in Senegal. The PfCSP sequences were compared with those retrieved from the Pf3k genome database. In the central repeat region of PfCSP...
Source: Am J Trop Med Hyg - Category: Infectious Diseases Authors: Source Type: research
[Capital FM] Kisumu -- The burden of Malaria has reduced by 18 per cent in Kisumu County which is endemic to the disease in the wake of a new vaccine recommended by the World Health Organization (WHO).
Source: AllAfrica News: Malaria - Category: Infectious Diseases Source Type: news
[Capital FM] Kisumu -- The burden of Malaria has reduced by 18 per cent in Kisumu County which is endemic to the disease in the wake of a new vaccine recommended by the World Health Organization (WHO).
Source: AllAfrica News: Malaria - Category: Infectious Diseases Source Type: news
Malaria is an endemic disease that affected 229 million people and caused 409 thousand deaths, in 2019. Disease control is based on early diagnosis and specific treatment with antimalarial drugs since no effective vaccines are commercially available to prevent the disease. Drug chemotherapy has a strong historical link to the use of traditional plant infusions and other natural products in various cultures. The research based on such knowledge has yielded two drugs in medicine: the alkaloid quinine from Cinchona species, native in the Amazon highland rain forest in South America, and artemisinin from Artemisia annua, a spe...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
In conclusion, our preliminary data suggest a diagnostic and prognostic role for rLiHyQ against leishmaniasis.PMID:34537185 | DOI:10.1016/j.actatropica.2021.106126
Source: Acta Tropica - Category: Infectious Diseases Authors: Source Type: research
Med Sci Monit. 2021 Sep 13;27:e934676. doi: 10.12659/MSM.934676.ABSTRACTMalaria affects more than 3 billion people in 95 countries, with an estimated mortality rate of 400,000 per year. The female Anopheles spp mosquito most commonly transmits malaria, and the main burden of disease is due to Plasmodium falciparum. The most abundant antigen on the sporozoite surface is the Plasmodium falciparum circumsporozoite protein (PfCSP). PfCSP is required for parasite development and attachment to host hepatocytes. The first potential protein vaccine, RTS,S/ASO1, consists of a recombinant fusion antigen based on PfCSP. Initial findi...
Source: Medical Science Monitor - Category: Research Authors: Source Type: research
Biochem Biophys Res Commun. 2021 Aug 27;577:58-63. doi: 10.1016/j.bbrc.2021.08.052. Online ahead of print.ABSTRACTThere is an urgent need for a malaria vaccine that can prevent severe disease in young children and adults. Despite earlier work showing an immunological mechanism for preventing infection and reducing disease severity, there is currently no reliable vaccine that can provide durable protection. In part, this may reflect a limited number of ways that the host can respond to the NANP repeat sequences of circumsporozoite protein (CSP) in the parasite. In addition, it may reflect antigenic escape by the parasite fr...
Source: Biochemical and Biophysical Research communications - Category: Biochemistry Authors: Source Type: research
This article does not present new scientific data but takes a historical perspective. Its aim is to highlight the above-mentioned transformation by focusing on selected malaria research-cum-action interventions during the crucial period of the 1990s, which were tailored to the social-ecological settings where the disease was endemic. In order for this transformation to be successful, we intend to emphasise the importance of (i) having a fundamental understanding of local transmission; (ii) building and nurturing relationships with partner institutions; and (iii) developing a coherent research portfolio as key elements for ...
Source: Acta Tropica - Category: Infectious Diseases Authors: Source Type: research
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