Viruses, Vol. 13, Pages 1806: High Rate of Mutational Events in SARS-CoV-2 Genomes across Brazilian Geographical Regions, February 2020 to June 2021
Viruses, Vol. 13, Pages 1806: High Rate of Mutational Events in SARS-CoV-2 Genomes across Brazilian Geographical Regions, February 2020 to June 2021
Viruses doi: 10.3390/v13091806
Authors:
Ueric Souza
Raíssa Santos
Fabrício Campos
Karine Lourenço
Flavio Fonseca
Fernando Spilki
Corona‐ômica.BR/MCTI Network
Brazil was considered one of the emerging epicenters of the coronavirus pandemic in 2021, experiencing over 3000 daily deaths caused by the virus at the peak of the second wave. In total, the country had more than 20.8 million confirmed cases of COVID-19, including over 582,764 fatalities. A set of emerging variants arose in the country, some of them posing new challenges for COVID-19 control. The goal of this study was to describe mutational events across samples from Brazilian SARS-CoV-2 sequences publicly obtainable on Global Initiative on Sharing Avian Influenza Data-EpiCoV (GISAID-EpiCoV) platform and to generate indexes of new mutations by each genome. A total of 16,953 SARS-CoV-2 genomes were obtained, which were not proportionally representative of the five Brazilian geographical regions. A comparative sequence analysis was conducted to identify common mutations located at 42 positions of the genome (38 were in coding regions, whereas two were in 5′ and two in 3′ UTR). Moreover, 11 were synonymous variants, 27 were missense variants, and more than 44.4% were located in the spike gene. Across the total of single nucleotide variations (SN...
Source: Viruses - Category: Virology Authors: Ueric Souza Ra íssa Santos Fabr ício Campos Karine Louren ço Flavio Fonseca Fernando Spilki Corona ‐ômica.BR/MCTI Network Tags: Article Source Type: research
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