Activation of CB1 pathway in the perirhinal cortex is necessary but not sufficient for destabilization of contextual fear memory in rats

Behav Brain Res. 2021 Sep 6:113573. doi: 10.1016/j.bbr.2021.113573. Online ahead of print.ABSTRACTAccording to the reconsolidation theory, memories can be modified through the destabilization-reconsolidation process. The rodent perirhinal cortex (PER; Brodmann areas 35 and 36) critically participates in the process of fear conditioning. Previous studies showed that some of the parahippocampal regions are critical for contextual fear memory reconsolidation. In our research, through a three-day paradigm of CFC, we showed that protein synthesis in PER of rats is required for memory reconsolidation, and activation of CB1 pathway is necessary but not sufficient in inducing memory destabilization. This result underlines parahippocampal regions in destabilization and reconsolidation process of fear memory besides amygdala and hippocampus.PMID:34499934 | DOI:10.1016/j.bbr.2021.113573

Source: Behavioural Brain Research - September 9, 2021 Category: Neurology Authors: Che Jiang Xiaona Wu Jiajia Wang Chunyong Li Gaoquan Luo Source Type: research