Foetal alcohol syndrome

There was an item on BBC's Look North yesterday, 9th September, about this, an interview with a mother whose baby was affected by her excess drinking during pregnancy.9th September is International Fetal Alcohol Spectrum Disorders (FASD) Awareness Day, marked by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) in the US.Librarians like to point out synonyms - foetal alcohol syndrome, fetal alcohol spectrum disorders (and the variation in spelling foetal!).   Here are some resources:NIAAACenters for Disease Control and Prevention (US) From the UK:NHS UKTommy's National Organisation for FASD - for people living with Foetal Alcohol SyndromeNICE Evidence Search finds material on personal experiences of mothers, and information on meeting the needs of children with FASD.
Source: Browsing - Category: Databases & Libraries Tags: midwifery Source Type: blogs

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Contributors : Bonnie L Alberry ; Aniruddho Chokroborty Hoque ; Shiva M SinghSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMaternal alcohol consumption during pregnancy results in a spectrum of lifelong behavioral and cognitive deficits collectively known as Fetal Alcohol Spectrum Disorders (FASD). FASD is a major health burden in most societies, there is no cure, and the molecular mechanism involved in its development is poorly understood. Human neurodevelopment is a continuum that extends over two decades after birth, with the potential to influence outcomes both prenatally and po...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
AbstractGlobal trends of increasing alcohol consumption among women of childbearing age, social acceptability of women ’s alcohol use, as well as recent changes in alcohol use patterns due to the COVID-19 pandemic may put many pregnancies at higher risk for prenatal alcohol exposure (PAE), which can cause fetal alcohol spectrum disorder (FASD). Therefore, screening of pregnant women for alcohol use has become more important than ever and should be a public health priority. This narrative review presents the state of the science on various existing prenatal alcohol use screening strategies, including the clinical util...
Source: International Journal of Mental Health and Addiction - Category: Addiction Source Type: research
CONCLUSIONS: These findings suggest that low-to-moderate PAE modulates NMDAR function in pyramidal neurons in a sex specific manner, although we did not find evidence that this is mediated by dysfunction of synaptic GluN2B subunit-containing NMDARs.PMID:34523139 | DOI:10.1111/acer.14697
Source: Cell Research - Category: Cytology Authors: Source Type: research
Neural Regen Res. 2022 Mar;17(3):497-502. doi: 10.4103/1673-5374.314294.ABSTRACTThe pathology of fetal alcohol syndrome and the less severe fetal alcohol spectrum disorders includes brain dysmyelination. Recent studies have shed light on the molecular mechanisms underlying these white matter abnormalities. Rodent models of fetal alcohol syndrome and human studies have shown suppressed oligodendrocyte differentiation and apoptosis of oligodendrocyte precursor cells. Ethanol exposure led to reduced expression of myelin basic protein and delayed myelin basic protein expression in rat and mouse models of fetal alcohol syndrome...
Source: Cell Research - Category: Cytology Authors: Source Type: research
CONCLUSION: SGA is a robust early indicator for FASD in this random sample of children assessed at 7 years of age.PMID:34342019 | DOI:10.1111/acer.14656
Source: Alcoholism, Clinical and Experimental Research - Category: Addiction Authors: Source Type: research
Brain Res. 2021 Jul 20:147587. doi: 10.1016/j.brainres.2021.147587. Online ahead of print.ABSTRACTPrenatal alcohol exposure (PAE) may result in Fetal Alcohol Spectrum Disorders (FASD). The hippocampus has been recognized as a vulnerable target to alcohol-induced developmental damage. However, the effect of prenatal exposure to alcohol on dendritic morphological adaptations throughout the hippocampal fields in the developing brain still remains largely unknown in the context of FASD. We hypothesized that chronic binge alcohol exposure during pregnancy alters dendrite arborization throughout the developing rat hippocampus. P...
Source: Brain Research - Category: Neurology Authors: Source Type: research
Fetal alcohol exposure can lead to developmental abnormalities, intellectual disability, and behavioral changes, collectively termed fetal alcohol spectrum disorder (FASD). In 2015, the Centers for Disease Control found that 1 in 10 pregnant women report alcohol use and more than 3 million women in the USA are at risk of exposing their developing fetus to alcohol. Drosophila melanogaster is an excellent genetic model to study developmental effects of alcohol exposure because many individuals of the same genotype can be reared rapidly and economically under controlled environmental conditions. Flies exposed to alcohol under...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Wechsberg This brief report emphasizes the need to focus on women with HIV who are pregnant who use alcohol or other drugs. A recently completed implementation science study tested a gender-focused behavioral intervention, the Women’s Health CoOp (WHC), to improve antiretroviral therapy (ART) adherence and reduce alcohol use among women with HIV. The study identified 33 participants who had a positive pregnancy test result at the baseline assessment, of whom five participants remained pregnant during the 6-month duration of the study. Of the 33 pregnant participants at the baseline assessment, 55% reported past-m...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Brief Report Source Type: research
Biomed Pharmacother. 2021 Jun 11;141:111813. doi: 10.1016/j.biopha.2021.111813. Online ahead of print.ABSTRACTFoetal alcohol spectrum disorder (FASD) is the umbrella term used to describe the physical and mental disabilities induced by alcohol exposure during development. Early alcohol exposure induces cognitive impairments resulting from damage to the central nervous system (CNS). The neuroinflammatory response accompanied by neurodegenerative mechanisms contribute to those detrimental alterations. Cannabidiol (CBD) has recently emerged as an anti-inflammatory drug that might be useful to treat several neuropsychiatric di...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - Category: Drugs & Pharmacology Authors: Source Type: research
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