A Clinical PET Imaging Tracer ([ < sup > 18 < /sup > F]DASA-23) to Monitor Pyruvate Kinase M2 Induced Glycolytic Reprogramming in Glioblastoma

CONCLUSIONS: We developed and translated [18F]DASA-23 as a new tracer that demonstrated the visualization of aberrantly expressed PKM2 for the first time in human subjects. These results warrant further clinical evaluation of [18F]DASA-23 to assess its utility for imaging therapy-induced normalization of aberrant cancer metabolism.PMID:34475101 | DOI:10.1158/1078-0432.CCR-21-0544

Source: Clinical Cancer Research - September 3, 2021 Category: Cancer & Oncology Authors: Corinne Beinat Chirag B Patel Tom Haywood Surya Murty Lewis Naya Jessa B Castillo Samantha T Reyes Megan Phillips Pablo Buccino Bin Shen Jun Hyung Park Mary Ellen Koran Israt S Alam Michelle L James Dawn Holley Kim Halbert Harsh Gandhi Joy Q He Monica Gra Source Type: research