Bacterial lipoproteins in sepsis

Immunobiology. 2021 Aug 20;226(5):152128. doi: 10.1016/j.imbio.2021.152128. Online ahead of print.ABSTRACTBacterial lipoproteins are membrane proteins derived from both gram-negative and gram-positive bacteria. They seem to have diverse functions not only on bacterial growth, but also play an important role in host's virulence. Bacterial lipoproteins exert their action on host immune cells via TLR2/1 or TLR2/6. Therefore, bacterial lipoproteins also need to be considered while addressing bacterial pathogenicity besides classical bacterial endotoxin like LPS and other microbial associated molecular patterns such as LTA, and peptidoglycans. In this mini-review, we provide an overview of general bacterial lipoprotein biosynthesis and the need to understand the lipoprotein-mediated pathogenicity in diseases like sepsis.PMID:34488139 | DOI:10.1016/j.imbio.2021.152128

Source: Immunobiology - September 6, 2021 Category: Allergy & Immunology Authors: Kandahalli Venkataranganayaka Abhilasha Gopal Kedihithlu Marathe Source Type: research