Blending of Designer Synthetic Polymers to a Dual Targeted Nanoformulation for SARS-CoV-2 Associated Kidney Damage

Biomacromolecules. 2021 Sep 7. doi: 10.1021/acs.biomac.1c00799. Online ahead of print.ABSTRACTAs the COVID-19 pandemic has continued to spread, studies have shown that hospitalized COVID-19 patients are at significant risk for developing acute kidney injury (AKI), which can cause increased morbidity, the need for dialysis treatment, chronic kidney diseases, and even death. In this paper, we present a proof-of-concept study for the utilization of combination therapeutic-loaded dual-targeted biodegradable nanoparticles (NPs) to treat concurrent AKI and COVID-19 in patients by delivering the therapeutics across the gut epithelial barrier and to the kidney, in order to lower the viral load as well as reduce the symptoms of AKI. Despite recent vaccination efforts and the end of the COVID-19 pandemic in sight, problems related to the long-term effects of COVID-19 will continue to persist, including impacts on patients suffering from AKI and other chronic renal conditions. Therefore, the dual-targeted blended polymeric NP developed in this study to treat concurrent COVID-19 infection and AKI is a useful proof-of-concept nanoplatform for future treatments of these complications.PMID:34492195 | DOI:10.1021/acs.biomac.1c00799
Source: Biomacromolecules - Category: Biochemistry Authors: Source Type: research

Related Links:

Abe Oudshoorn, Tanya Benjamin, Tracy A. Smith-Carrier, Sarah Benbow, Carrie Anne Marshall, Riley Kennedy, Jodi Hall, C. Susana Caxaj, Helene Berman, Deanna Befus Housing, Care and Support, Vol. ahead-of-print, No. ahead-of-print, pp.- People experiencing homelessness are uniquely vulnerable to the impacts of a pandemic, such as COVID-19. Therefore, governments across Canada have been implementing a patchwork of responses to address the needs of those who are homeless at this time. The purpose of this study is to both compile and assess the varying responses by exploring the breadth of actions presented i...
Source: Housing, Care and Support - Category: International Medicine & Public Health Authors: Source Type: research
ConclusionIn the follow-up of children and adolescents with CCM during the first UK lockdown using telemedicine we found that over half had stable health conditions. Patients needing additional care could not be predicted by the severity of their disease or their bowel function alone.
Source: Pediatric Surgery International - Category: Surgery Source Type: research
A new"rapid expert consultation" has identified"actionable guidance" that state and local decision-makers can use to communicate with the public.Medscape Medical News
Source: Medscape Pediatrics Headlines - Category: Pediatrics Tags: Pediatrics News Source Type: news
Three faculty members of theDavid Geffen School of Medicine at UCLA have been elected to the National Academy of Medicine, among the highest honors in the fields of medicine and health.New members are elected by their peers through a process that recognizes individuals who have demonstrated outstanding professional achievement and commitment to service.The honorees are:Dr. Helena Hansen, professor of psychiatry and biobehavioral sciences. She co-chairs the medical school ’s Research Theme in Health Equity and Translational Social Science, which cultivates research collaborations between social and biomedica...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
At Legacy, fewer than 500 employees are not vaccinated.
Source: bizjournals.com Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news
After a Covid-19-related delay, UNC Rex Healthcare has announced its new hospital in Holly Springs will open Nov. 1.
Source: bizjournals.com Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news
Puerto Rico's rate tops all states and territories. One expert thinks it may in large part be due to not tying vaccine beliefs to politics.Medscape Medical News
Source: Medscape Pediatrics Headlines - Category: Pediatrics Tags: Infectious Diseases News Source Type: news
As the COVID-19 vaccine heads toward approval for children under age 12 years, the number of older children receiving it dropped for the 10th consecutive week.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Pediatrics News Source Type: news
President Joe Biden’s most aggressive move yet to combat the COVID-19 pandemic is almost ready to see the light of day
Source: ABC News: Health - Category: Consumer Health News Tags: Health Source Type: news
More News: Biochemistry | Chronic Kidney Disease | COVID-19 | Dialysis | Eyes | Hypermetropia (long sighted) | Nanotechnology | Pandemics | SARS | Study | Urology & Nephrology | Vaccines