Emerging Roles of N6-Methyladenosine Demethylases and Its Interaction with Environmental Toxicants in Digestive System Cancers
Ovarian cancer is characterized by aberrant activation of the mitogen-activated protein kinase (MAPK), highlighting the importance of targeting the MAPK pathway as an attractive therapeutic strategy. However, the clinical efficacy of MEK inhibitors is limited by intrinsic or acquired drug resistance. Here, we established patient-derived ovarian cancer models resistant to MEK inhibitors and demonstrated that resistance to the clinically approved MEK inhibitor trametinib was associated with enhancer reprogramming. We also showed that enhancer decommissioning induced the downregulation of negative regulators of the MAPK pathw...
Tumor-infiltrating myeloid cells contribute to the development of the immunosuppressive tumor microenvironment. Myeloid cell expression of arginase 1 (ARG1) promotes a protumor phenotype by inhibiting T cell function and depleting extracellular l-arginine, but the mechanism underlying this expression, especially in breast cancer, is poorly understood. In breast cancer clinical samples and in our mouse models, we identified tumor-derived GM-CSF as the primary regulator of myeloid cell ARG1 expression and local immune suppression through a gene-KO screen of breast tumor cell–produced factors. The induction of myeloid c...
During prostate cancer treatment, some gut bacteria start making hormones that may support cancer growth and treatment resistance.WebMD Health News
A SON in the throes of grief has made a documentary urging people to recognise the early warning signs of pancreatic cancer after his dad, Paul Kennedy, died of the disease last year. Issuing an important public health message, Paul's son Daniel drew attention to his dad's first symptom.
It is 25 years since the publication of Milan criteria for liver transplantation in hepatocellular carcinoma (HCC), but the optimum management of patients progressing beyond Milan criteria on the waiting list remains a controversial topic. Ferrer-F àbrega and coworkers aimed to determine whether the policy of allowing limited progression beyond enlistment criteria permits acceptable outcomes. Patients were retained on the waiting list despite exceeding enlistment criteria if they did not present with macrovascular invasion, extrahepatic sprea d or cancer-related symptoms.
The drug is now also approved for adjuvant treatment following resection and platinum-based chemotherapy in early stage, non-small cell lung cancer with PD-L1 ≥ 1%.FDA Approvals
An experimental radiotracer based on gallium-68 can help identify primary an...Read more on AuntMinnie.comRelated Reading: Sofie submits IND application for pancreatic PET agent New PET radiotracer more effective at detecting cancer PET detects activity in early atherosclerosis Animal study suggests Ga-68 PET FAPI can detect lung fibrosis PET/CT with Ga-68 tracer better for cancer patients