Obstructive Apneas in a Mouse Model of Congenital Central Hypoventilation Syndrome

CONCLUSIONS: The Phox2b27Ala/+ mutation predisposed pups not only to hypoventilation and central apneas, but also to obstructive and mixed apneas, likely due to hypoglossal dysgenesis. These results thus demand attention towards obstructive events in infants with CCHS.PMID:34478357 | DOI:10.1164/rccm.202104-0887OC

Source: Am J Respir Crit Car... - September 3, 2021 Category: Intensive Care Authors: Am élia Madani Gabriel Pitollat El éonore Sizun Laura Cardoit Maud Ringot Thomas Bourgeois Nelina Ramanantsoa Christophe Delclaux St éphane Dauger Marie-Pia d'Ortho Muriel Thoby-Brisson Jorge Gallego Boris Matrot Source Type: research