Usefulness of high-risk human papillomavirus mRNA silver in situ hybridization diagnostic assay  in oropharyngeal squamous cell carcinomas

CONCLUSIONS: The recently developed mRNA SISH methodology can detect HPV-driven OPSCCs without any additional test in 79% of cases. Positive SISH signals enable the visualization of viral transcripts required to recognize clinically relevant HPV infection. However, rare and tiny signals require an experienced pathologist to establish a consensus interpretation of results. The currently applied HR-HPV mRNA SISH analysis may serve as a groundwork for additional studies.PMID:34455364 | DOI:10.1016/j.prp.2021.153585

Source: Pathology, Research and Practice - August 29, 2021 Category: Pathology Authors: Nina Gale Mario Poljak Metka Volav šek Lea Ho šnjak Dane Velkavrh Luka Bolha Kristina Fujs Komlo š Primo ž Strojan Aleksandar Ani čin Nina Zidar Source Type: research