Peptide-based immunotherapy against oxidized elastin ameliorates pathology in mouse model of smoke-induced ocular injury

CONCLUSIONS: These data further support ox-elastin role in ocular damage in in part via elastin-specific antibodies, and support the corollary that PIT with ox-elastin attenuates ocular pathology. Overall, damage is associated with complement activation, antibody-dependent cell-mediated cytotoxicity, and altered cytokine signature.PMID:34487725 | DOI:10.1016/j.exer.2021.108755

Source: Experimental Eye Research - September 6, 2021 Category: Opthalmology Authors: B ärbel Rohrer Nathaniel Parsons Balasubramaniam Annamalai Crystal Nicholson Elisabeth Obert Bryan Jones Andrew D Dick Source Type: research