Partial breast irradiation versus whole breast radiotherapy for early breast cancer
CONCLUSIONS: It appeared that local recurrence-free survival is probably worse with PBI/APBI; however, the difference was small and nearly all women remain free of local recurrence. Overall survival is similar with PBI/APBI and WBRT, and we found little to no difference in other oncological outcomes. Some late effects (subcutaneous fibrosis) may be worse with PBI/APBI and its use is probably associated with worse cosmetic outcomes. The limitations of the data currently available mean that we cannot make definitive conclusions about the efficacy and safety or ways to deliver PBI/APBI. We await completion of ongoing trials.PMID:34459500 | PMC:PMC8406917 | DOI:10.1002/14651858.CD007077.pub4
ConclusionAggressive BC subtypes occur among women with LFS. Surgical treatment, i.e. ME and CPM, may prolong time to a second BC diagnosis. Conclusion on long-term survival benefit is pending. Individual competing tumour risks and long-term outcomes need to be taken into consideration.
Mastectomy and breast conserving surgery (BCS) followed by whole breast radiotherapy (WBRT) are the standard therapeutic options for patients with ductal carcinoma in situ (DCIS), although no randomized clinical trial has compared these two strategies. Adjuvant WBRT, in which 50 Gy are delivered in 25 fractions over 5 weeks after BCS, significantly increases the local control rate with low toxicity incidence [1,2]. After the European Organization for Research and Treatment of Cancer (EORTC) trial results, a radiotherapy boost is standard practice in patients with invasive breast cancer after BCS.
1. DCISM patients had a good survival, even those with DCIS component ≥5 cm.2. Patients aged
CONCLUSIONS: Recurrence following BCS with CSMs can be stratified based on both lumpectomy and cavity shave margin positivity. Routine excision of CSMs allows identification of these patient subsets.PMID:34196595 | DOI:10.1177/00031348211030464
CONCLUSION: Bracketing techniques using multiple radioactive seeds expands the indications for breast conservation therapy in patients who would have traditionally required mastectomy. Intraoperative margin assessment improves surgical and pathologic success. Larger defects created by multifocal resection are optimally managed in concert with oncoplastic reconstruction to minimize asymmetries and aesthetic defects.PMID:34187752 | DOI:10.1016/j.clbc.2021.05.013
ConclusionsAs DCIS can respond to NST containing HER2-blockade, the presence of extensive DCIS in HER2-positive breast cancer before NST should not always indicate a mastectomy. The predictive factors we found could be helpful when considering breast-conserving surgery in these patients.
CONCLUSION: We suggest that repeated BCS with radiation therapy deserves consideration when DCIS survivors suffered IBTR. The choice of surgical management should be tailored based on patients' age at IBTR diagnosis and size of recurrent disease.PMID:33846099 | DOI:10.1016/j.clbc.2021.02.012
CONCLUSION: As reported in other countries, breast cancer in LFS patients in South Korea had an early onset and were predominantly but not exclusively positive for HER2. A multidisciplinary approach with adherence to the treatment guidelines, considering mastectomy, and avoiding RT is encouraged to prevent RT-associated sequelae in LFS patients.PMID:33818021 | DOI:10.4048/jbc.2021.24.e16
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