A comparison of acute mouse hindlimb injuries between tourniquet- and femoral artery ligation-induced ischemia-reperfusion

Ischemia-reperfusion (IR) is a well-known phenomenon in a wide range of organs, including the heart, lung, kidney, gut, skeletal muscle, and brain [1]. Although reperfusion, reestablishment of blood flow, is essential to salvage ischemic tissues or organs, it can cause further damage, threatening function and viability of the organ following the ischemic event, often referred to as IR injury [2,3]. In the skeletal muscle, IR injury due to tourniquet or femoral artery constriction has been reported in many debilitating diseases and some clinical procedures [2,3], further leading to systemic damage to distant organs [2,4,5], although the tourniquet and femoral artery ligation are widely used in prehospital emergency situations and some surgical procedures to stop extremity hemorrhage or create a bloodless operating field.
Source: Injury - Category: Orthopaedics Authors: Source Type: research