Epithelial-mesenchymal transition (EMT) in vulvar cancer with and without inguinal lymph node involvement

CONCLUSION: The present study shows no differences in the expression of EMT markers between node positive and node negative vulvar cancers. The evaluation of immunostaining within the micro-anatomical context indicates that an EMT-phenotype is restricted to the tumor cells at the front of invasion. Paired analyses of vulvar carcinomas and their lymph node deposits suggest mesenchymal-epithelial transition (MET) in the metastatic deposits. Immunohistochemical staining results may suggest that EMT is more prevalent in vulvar cancer with aberrant p53 staining.PMID:34495397 | DOI:10.1007/s00432-021-03715-2

Source: Clinical Breast Cancer - September 8, 2021 Category: Cancer & Oncology Authors: Christine E Brambs Lars-Christian Horn Meinhard Mende Michael H öckel Christine Eckey Gesine Grit Ruth Hiller Anne Kathrin H öhn Source Type: research