Longitudinal association of apolipoprotein E and sleep with incident dementia

DISCUSSION: Short and long sleep duration and daytime napping in middle-aged individuals are associated with the development of dementia in later life. Sleep duration and quality are important for everyone regardless of their genetic risk by APOE genotype.PMID:34477303 | DOI:10.1002/alz.12439
Source: The Journal of Alzheimers Association - Category: Psychiatry Authors: Source Type: research

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CONCLUSION: Multiple and sustained nonpharmacological approaches are recommended for the treatment of sleep disturbances in patients with neurocognitive disorder. Pharmacological indications remain limited, and further randomized clinical trials integrating a multimodal approach are warranted to evaluate the treatment of sleep disorders in specific neurocognitive disorders.PMID:34916075 | DOI:10.1016/j.encep.2021.08.014
Source: L Encephale - Category: Psychiatry Authors: Source Type: research
Conclusion: There is strong evidence to suggest that CBT is associated with improvements in anxiety, depression, and quality of life in persons with mild cognitive impairment and dementia. CBT showed a reduction in insomnia and improvements in sleep quality. However, there is insufficient evidence to draw conclusions on the effects of CBT on insomnia. These results suggest that further investigation into insomnia outcomes is needed.
Source: Alzheimer Disease and Associated Disorders - Category: Geriatrics Tags: Review Articles Source Type: research
J Sleep Res. 2021 Aug 2:e13328. doi: 10.1111/jsr.13328. Online ahead of print.ABSTRACTThe orexin receptor antagonist suvorexant was previously reported to significantly improve total sleep time (TST), by 28 min per night versus placebo after 4 weeks, in a sleep laboratory polysomnography (PSG) study of patients with Alzheimer's disease and insomnia. The study included an exploratory evaluation of a consumer-grade wearable "watch" device for assessing sleep that we report on here. Participants who met diagnostic criteria for both probable Alzheimer's disease dementia and insomnia were randomized to suvorexant 10-2...
Source: Journal of Sleep Research - Category: Sleep Medicine Authors: Source Type: research
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