Apoptosis induction by the stem cell factor LIN28A

CONCLUSIONS AND SIGNIFICANCE: This unexpected observation suggests that cell fate regulation by Lin28 is dependent on a specific cellular/genetic context. Unraveling the cellular and molecular mechanisms underlying this Lin28A overexpression effect may pave the way for novel tumor therapeutic strategies, as Lin28 is commonly expressed in many types of tumors but not in most normal adult cells.PMID:34437724 | DOI:10.1111/boc.202100011
Source: Biology of the Cell - Category: Cytology Authors: Source Type: research