Safety and tolerability of the COVID ‐19 mRNA‐vaccine in adolescents with juvenile idiopathic arthritis on treatment with TNF‐inhibitors

AbstractPatients with rheumatic and musculoskeletal diseases (RMDs) on immunosuppressants are considered a vulnerable group in COVID-19 pandemic and vaccination is the mainstay for the prevention of this infection (1). To date, recommendations and data for COVID-19 vaccination in adolescent patients with RMDs are lacking (2). International societies and post-authorization safety reports of the novel mRNA COVID-19 vaccines are generally reassuring; nonetheless their safely profile in adolescents with RMDs on immune-modulating treatment is unknown, since these individuals were excluded from the vaccine trials (3-5).
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Tags: LETTER TO THE EDITOR Source Type: research

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New Brunswick, N.J. (October 19, 2021) – Johnson &Johnson (NYSE: JNJ) today announced results for third-quarter 2021. “Our third-quarter results demonstrate solid performance across Johnson &Johnson, driven by robust above-market results in Pharmaceuticals, ongoing recovery in Medical Devices, and strong growth in Consumer Health,” said Alex Gorsky, Chairman and Chief Executive Officer. “In the face of evolving marketplace dynamics resulting from the effects of COVID-19 and other global trends, we have continued to demonstrate the responsiveness and agility required to meet the needs of our ...
Source: Johnson and Johnson - Category: Pharmaceuticals Tags: Financial Source Type: news
In a recent series of articles, we explored the latest moves of Tech Giants like Amazon, NVIDIA and Microsoft in the field of digital health. Analysing these recent developments can give us a better idea regarding where they are focusing the efforts, and how it might shape the future path of healthcare.  But equally, if not more, strong players in this field are pharmaceutical giants, as their resources and influence can significantly shape or alter the course of this path. As such, we are kickstarting a new series of articles focusing on the digital health efforts of 14 global pharma companies. While those heavywe...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Future of Medicine Future of Pharma digital health novartis pfizer J&J big pharma Johnson&Johnson Bayer Source Type: blogs
Auranofin is an FDA-approved disease-modifying anti-rheumatic drug that has been used for decades for treatment of rheumatoid arthritis. This gold(I) compound has anti-inflammatory properties because it reduces IL-6 expression via inhibition of the NF-κB-IL-6-STAT3 signaling pathway. Also, by inhibiting redox enzymes such as thioredoxin reductase, auranofin increases cellular oxidative stress and promotes apoptosis. Auranofin also possesses antiviral properties. Recently, it was reported that auranofin reduced by 95% SARS-CoV-2 RNA in infected human cells in vitro and decreased SARS-CoV-2-induced cytokine expression,...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
AbstractManaging patients with rheumatic disease during the COVID-19 pandemic has posed a unique challenge. Immunosuppressed patients are at an increased risk for developing severe COVID-19 and may not derive full protection from the vaccine (1-5). Thus, it is paramount we develop strategies whereby rheumatic disease patients can be protected from the pandemic virus and its variants.
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Tags: LETTER TO THE EDITOR Source Type: research
CONCLUSION: While additional data is warranted to determine the effects of immunocompromising medical conditions and immunosuppressing medications on the efficacy of the vaccine, the benefits of the vaccine is anticipated to outweigh theoretical risks. Thus, the COVID-19 vaccine is recommended to be given to immunocompromised patients at this time, and providers should make efforts to decrease vaccine hesitancy in this population through education and reassurance.PMID:34455440 | DOI:10.1093/ajhp/zxab344
Source: American Journal of Health-System Pharmacy : AJHP - Category: Drugs & Pharmacology Authors: Source Type: research
ConclusionOur data from early 2021 indicate that a large proportion of Swedish SLE patients had serological signs of exposure to SARS-CoV-2 but apparently with a minor impact on the SLE course. Use of steroids and hydroxychloroquine showed no distinct effects, and self-reported COVID-19-related symptoms correlated poorly with all antibody isotypes.
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
UK deaths are highest since mid-March;doctors, scientists and the government disagree over vaccinating children in GermanyUS Covid hospitalisations rise as doctors say patients are unvaccinatedNew York to require vaccination for indoor dining and eventsScotland to scrap social distancing as it lifts most restrictionsHundreds of health workers in isolation as Delta hits QueenslandHopes UK vaccine trial in pregnant women will allay jab fears5.58pmBSTOvernight, the board of governors of the International Monetary Fund (IMF) approved the largest resource injection in its history to boost global liquidity and help countries whi...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Coronavirus World news Science Infectious diseases New Zealand Japan US news Source Type: news
Fifty percent of vaccine-hesitant Americans believe the message that “Getting the COVID-19 vaccine is the best way to prevent COVID-19 and its potential long-term complications”. Credit: UNICEF/Nahom Tesfaye By Ifeanyi NsoforABUJA, Jul 30 2021 (IPS) A new survey on public awareness of long COVID by ‘Resolve to Save Lives” showed that among the 40% of Americans who were not vaccinated, seeing testimonials of those who suffer from long COVID inspired nearly two-thirds to consider the vaccine. A representative sample of nearly 2,000 Americans 18 and older took the survey between May 21 and Ju...
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Global Headlines Health Source Type: news
The onset of the 2019 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic necessitated the identification of approved drugs to treat the disease, before the development, approval and widespread administration of suitable vaccines. To identify such a drug, we used a visual analytics workflow where computational tools applied over an AI-enhanced biomedical knowledge graph were combined with human expertise. The workflow comprised rapid augmentation of knowledge graph information from recent literature using machine learning (ML) based extraction, with human-guided iterative queries of the graph. Using this ...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
New Brunswick, N.J. (July 21, 2021) – Johnson &Johnson (NYSE: JNJ) today announced results for second-quarter. “Our second-quarter results showcase Johnson &Johnson’s diversified portfolio, driven by strong sales and earnings growth across our Medical Device, Consumer Health and Pharmaceutical businesses,” said Alex Gorsky, Chairman and Chief Executive Officer. “I’m so proud of our 136,000 colleagues who remain focused on delivering our medicines and products to patients and consumers around the world, in addition to advancing our pipeline with new product launches and regulatory...
Source: Johnson and Johnson - Category: Pharmaceuticals Tags: Our Company Source Type: news
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