Unravelling Lipoprotein Metabolism with Stable Isotopes: Tracing the Flow

Dysregulated lipoprotein metabolism is a major case of atherosclerotic cardiovascular disease (ASCVD). Use of stable isotope tracers and compartmental modelling have provided deeper understanding of the mechanisms underlying lipid disorders in patients at high risk of ASCVD, including familial hypercholesterolemia (FH), elevated lipoprotein(a) [Lp(a)] and metabolic syndrome (MetS). In patients with FH, deficiency in low-density lipoprotein (LDL) receptor activity does not only impair the catabolism of LDL, but also induces hepatic overproduction and decreases catabolism of triglyceride-rich lipoproteins (TRLs).
Source: Metabolism - Clinical and Experimental - Category: Biomedical Science Authors: Source Type: research