Bactericidal activity of avian complement: a contribution to understand avian-host tropism of Lyme borreliae

Complement has been considered as an important factor impacting the host –pathogen association of spirochetes belonging to the Borrelia burgdorferi sensu lato complex, and may play a role in the spirochete’s ecolo...
Source: Parasites and Vectors - Category: Microbiology Authors: Tags: Short report Source Type: research

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Trends Parasitol. 2021 Sep 18:S1471-4922(21)00207-5. doi: 10.1016/j.pt.2021.08.009. Online ahead of print.ABSTRACTInteractions between the Anopheles mosquito vector and Plasmodium parasites shape how malaria is transmitted in endemic regions. The long association of these two organisms has led to evolutionary processes that minimize fitness costs of infection and benefit both players through shared nutrient resources, parasite immune suppression, and mosquito tolerance to infection. In this review we explore recent data describing how Plasmodium falciparum, the deadliest malaria parasite, associates with one of its most im...
Source: Trends in Parasitology - Category: Parasitology Authors: Source Type: research
[The Conversation Africa] Eleven years ago, in the rugged hills of West Pokot County in Kenya, Mary Alamak, a mother of four, fell ill with the parasitic disease kala-azar while she was pregnant. Her weight fell from 80 to 45 kgs in a matter of weeks. She feared for the life of her baby and her own. At the Kacheliba District Hospital, she could get diagnosed, and treated with AmBisome injections. She was cured and regained weight - and her baby was saved.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
Malaria is an endemic disease that affected 229 million people and caused 409 thousand deaths, in 2019. Disease control is based on early diagnosis and specific treatment with antimalarial drugs since no effective vaccines are commercially available to prevent the disease. Drug chemotherapy has a strong historical link to the use of traditional plant infusions and other natural products in various cultures. The research based on such knowledge has yielded two drugs in medicine: the alkaloid quinine from Cinchona species, native in the Amazon highland rain forest in South America, and artemisinin from Artemisia annua, a spe...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Emerging evidence indicates that innate host response contributes to the therapeutic effect of antimicrobial medications. Recent studies have shown that Leishmania parasites derived by in vitro selection for resistance to pentavalent antimony (SbV) as meglumine antimoniate (MA) modulate the activation of neutrophils. However, whether modulation of neutrophil activation extends to natural resistance to this antileishmanial drug has not been established. We have evaluated the influence of clinical strains of L. (V.) panamensis having intrinsic tolerance/resistance to SbV, on the inflammatory response of neutrophils during ex...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
rause Influenza virus is a highly contagious virus that causes significant human mortality and morbidity annually. The most effective drugs for treating influenza are the neuraminidase inhibitors, but resistance to these inhibitors has emerged, and additional drug discovery research on neuraminidase and other targets is needed. Traditional methods of neuraminidase production from embryonated eggs are cumbersome, while insect cell derived protein is less reflective of neuraminidase produced during human infection. Herein we describe a method for producing neuraminidase from a human cell line, HEK293-6E, and demonstrate ...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
Malaria is a mosquito-borne disease caused by single-celled blood parasites of the genus Plasmodium. The most severe cases of this disease are caused by the Plasmodium species, Falciparum. Once infected, a human host experiences symptoms of recurrent and intermittent fevers occurring over a time-frame of 48 hours, attributed to the synchronized developmental cycle of the parasite during the blood stage. To understand the regulated periodicity of Plasmodium falciparum transcription, this paper forecast and predict the P. falciparum gene transcription during its blood stage life cycle implementing a well-tuned recurrent neur...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
In this study, we initially optimized the condition of the transfection protocol. We demonstrated that with the optimized condition, the transfection of FnCas12a (also known as “FnCpf1”) protein and crRNA targeting EtHistone H4 triggered DNA double-strand breaks in vivo. We then used this strategy to knock-in a coding cassette for an enhanced yellow fluorescent protein (EYFP) and dihydrofolate reductase–thymidylate synthase gene (DHFR) as a selection marker to tag endogenous EtActin. The engineered E. tenella parasite possesses EYFP expression in its entire life cycle. Our results demonstrated that FnCas1...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
Speaker Alexandra L. Phelan is an Adjunct Professor in Global and Public Health Law and Ethics, Doctor of Juridical Science (SJD) candidate and General Sir John Monash Scholar at Georgetown University in Washington DC. Professor Phelan ’ s doctoral research examines the global governance of infectious diseases, with a focus on Australian, Chinese and US laws relating to the health and human rights of vulnerable population groups. Professor Phelan ’ s research explores the key legal issues of emerging and re-emerging infectious diseases – such as Ebola, Pandemic Influenza, MERS, and Zika Virus – in t...
Source: Videocast - All Events - Category: General Medicine Tags: Upcoming Events Source Type: video
Teaching point: Meticulous anamnesis and a high index of suspicion is needed for the diagnosis of Lyme arthritis. Published on 2021-09-21 11:30:32
Source: Journal of the Belgian Society of Radiology - Category: Radiology Source Type: research
Mepron, a thick liquid antimicrobial drug used to treat Babesia and malaria, as well as a fungal infection called Pneumocystitis carinii. In 2011, the United Kingdom stopped requiring that dogs brought into the country be inspected for ticks. Earlier this year, several dogs tested positive for babesia, a malaria-like disease transmitted to ticks that previously had only been found in foreign. These dogs had never left the U.K. While babesiosis is a new worry to U.K. dog owners, it's been a threat to human beings for years -- it just hasn't become a health-scare-of-the-week like Zika, West Nile, avian and swine flu. Most...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
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