Bactericidal activity of avian complement: a contribution to understand avian-host tropism of Lyme borreliae

Complement has been considered as an important factor impacting the host –pathogen association of spirochetes belonging to the Borrelia burgdorferi sensu lato complex, and may play a role in the spirochete’s ecolo...
Source: Parasites and Vectors - Category: Microbiology Authors: Tags: Short report Source Type: research

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Source: Journal of Neurology - Category: Neurology Source Type: research
[Ghanaian Times] Takoradi -- The Western Regional Directorate of Public Health has alerted stakeholders and the public about the outbreak of avian influenza (AI) in the Sekondi- Takoradi Metropolis and the Effia-Kwesimintsim Municipality in the Western Region.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
Int J Environ Res Public Health. 2022 Jan 12;19(2):818. doi: 10.3390/ijerph19020818.ABSTRACTAvian mutations in vaccine strains obtained from embryonated eggs could impair vaccine effectiveness. We performed a systematic review and meta-analysis of the adjusted relative vaccine effectiveness (arVE) of seed cell-cultured influenza vaccines (ccIV) compared to egg-based influenza vaccines (eIV) in preventing laboratory-confirmed influenza related outcomes (IRO) or IRO by clinical codes, in subjects 18 and over. We completed the literature search in January 2021; applied exclusion criteria, evaluated risk of bias of the evidenc...
Source: Cell Research - Category: Cytology Authors: Source Type: research
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Source: Protein Science - Category: Biochemistry Authors: Tags: Full ‐Length Paper Source Type: research
Conclusion: Our results not only suggested that host miRNA expression was dynamically altered by H. meleagridis and host, but also revealed that more miRNAs and genes were involved in the later stage of the disease. In addition, host and H. meleagridis regulated the expression of immune and inflammation-related cytokines to respond to H. meleagridis infection. Our results will contribute to future research on miRNA-target interaction during H. meleagridis infection in chickens and provide new ideas for H. meleagridis control.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Mus musculus Source Type: research
Contributors : Shivendra G Tewari ; Bobby Kwan ; Rubayet Elahi ; Krithika Rajaram ; Amanda Dziedzic ; Anne E Jedlicka ; Jaques Reifman ; Sean T Prigge ; Akhil B Vaidya ; Anders WallqvistSeries Type : Expression profiling by arrayOrganism : Plasmodium falciparumDue to the recurring loss of antimalarial drugs to resistance, there is a need for novel targets, drugs, and combination therapies to ensure the availability of current and future countermeasures. Pyrazoleamides belong to a novel class of antimalarial drugs that disrupt sodium ion homeostasis, although the exact consequences of this disruption in Plasmodium falciparu...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Plasmodium falciparum Source Type: research
an Lewis Brown Hansen Reid The UK and Europe have seen successive outbreaks of highly pathogenic avian influenza across the 2020/21 and 2021/22 autumn/winter seasons. Understanding both the epidemiology and transmission of these viruses in different species is critical to aid mitigating measures where outbreaks cause extensive mortalities in both land- and waterfowl. Infection of different species can result in mild or asymptomatic outcomes, or acute infections that result in high morbidity and mortality levels. Definition of disease outcome in different species is of great importance to understanding the r...
Source: Viruses - Category: Virology Authors: Tags: Communication Source Type: research
PM Sundar, S Sivanandam, TV ChitraJournal of Postgraduate Medicine 2022 68(1):60-61
Source: Journal of Postgraduate Medicine - Category: Internal Medicine Authors: Source Type: research
Seemann The non-mevalonate or also called MEP pathway is an essential route for the biosynthesis of isoprenoid precursors in most bacteria and in microorganisms belonging to the Apicomplexa phylum, such as the parasite responsible for malaria. The absence of this pathway in mammalians makes it an interesting target for the discovery of novel anti-infectives. As last enzyme of this pathway, IspH is an oxygen sensitive [4Fe-4S] metalloenzyme that catalyzes 2H+/2e- reductions and a water elimination by involving non-conventional bioinorganic and bioorganometallic intermediates. After a detailed description of the disco...
Source: Molecules - Category: Chemistry Authors: Tags: Review Source Type: research
Mepron, a thick liquid antimicrobial drug used to treat Babesia and malaria, as well as a fungal infection called Pneumocystitis carinii. In 2011, the United Kingdom stopped requiring that dogs brought into the country be inspected for ticks. Earlier this year, several dogs tested positive for babesia, a malaria-like disease transmitted to ticks that previously had only been found in foreign. These dogs had never left the U.K. While babesiosis is a new worry to U.K. dog owners, it's been a threat to human beings for years -- it just hasn't become a health-scare-of-the-week like Zika, West Nile, avian and swine flu. Most...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
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