The pan-PPAR agonist lanifibranor reduces development of lung fibrosis and attenuates cardiorespiratory manifestations in a transgenic mouse model of systemic sclerosis

The T βRII∆k-fib transgenic (TG) mouse model of scleroderma replicates key fibrotic and vasculopathic complications of systemic sclerosis through fibroblast-directed upregulation of TGFβ signalling. We have exa...

Source: Arthritis Research and Therapy - September 6, 2021 Category: Rheumatology Authors: Emma Derrett-Smith, Kristina E. N. Clark, Xu Shiwen, David J. Abraham, Rachel K. Hoyles, Olivier Lacombe, Pierre Broqua, Jean Louis Junien, Irena Konstantinova, Voon H. Ong and Christopher P. Denton Tags: Research article Source Type: research