How does Lichen Sclerosus et Atrophicus Present?

Discussion Lichen sclerosus et atrophicus (LSA) is a chronic inflammatory disease with a strong autoimmune association. It can occur with other autoimmune diseases. Its specific cause is unknown. It affects females and males of all ages, but especially females 40-60 years. In the pediatric population it affects prepubertal females most often. Treatment includes steroid medications or anti-inflammatory medications. Other treatments may be offered including phototherapy, and much less commonly systemic steroids or immunosuppressive therapy. Circumcision may also be an option for some males. Childhood LSA generally improves but can continue into adulthood. Scarring can occur with narrowing of the openings of the urethra, vagina, and anus and also the foreskin in males. Malignancy has been reported in adults but not children. The differential diagnosis includes post-inflammatory hypopigmentation, lichen planus, tinea versicolor, vitiligo or morphea (localized sclerosis). Malignancies should also be considered in older populations. Vulvovaginitis and sexual abuse should be considered in the differential diagnosis for children because of the genital irritation presentation but usually do not have the same physical examination appearance. Learning Point LSA lesions are shiny, and pale or white. The lesion edges can appear more diffuse or well-demarcated. The tissue appears shiny, thin, wrinkled and parchment-like, while others will describe it as a “porcelain white appearing c...
Source: - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news

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We thank the respondents to our article1 for their insightful comments. Although we have matched subjects in both cohorts by age, sex, comorbidities, and index date, Lin et  al2 indicate a lack of adjustment for co-medication status, including the use of corticosteroids and disease-modifying antirheumatic drugs (DMARDs), in the propensity score. We agree that these medications are important confounders on fracture. We therefore had conducted multivariate analysis in t he published article by adjustment for corticosteroids, DMARDs, and phototherapy.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Commentary Source Type: research
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Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Pain Medicine Source Type: forums
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Source: The Scientist - Category: Science Tags: News & Opinion Source Type: news
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Source: Guardian Unlimited Science - Category: Science Authors: Tags: Dogs Animals Science UK news World news Pets Life and style Veterinary medicine Source Type: news
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