COVID-19 mRNA vaccination leading to CNS inflammation: a case series
We report clinical and MRI features of seven individuals who received the Moderna (n = 3) or Pfizer (n = 4) SARS-CoV-2 mRNA vaccines. Within one to 21 days of either the first (n = 2) or second (n = 5) vaccine dose, these patients developed neurologic symptoms and MRI findings consistent with active CNS demyelination of the optic nerve, brain, and/or spinal cord. Symptoms included visual loss, dysmetria, gait instability, paresthesias, sphincter disturbance, and limb weakness. Age ranged from 24 to 64 (mean 39.1) years; five were woman (71.4%). The final diagnosis was exacerbation of known stable MS (n = 4, two were receiving disease-modifying therapy at the time of vaccination), new onset MS (n = 2), or new onset neuromyelitis optica (n = 1). All responded to corticosteroid (n = 7) or plasma exchange (n = 1) therapy, with five returning to baseline and two approaching baseline. Large prospective studies are required to further investigate any possible relationship between COVID-19 vaccines and acute CNS demyelination.
The $335.8 million, 182,800-square-foot structure is the first start-to-finish UCSF construction project since the start of the Covid-19 pandemic, with the clinical building opening in 2024.
The election year “just took people’s time away from and distracted them away from the pandemic in my personal opinion,” Birx told a House subcommittee.
Just griping about the lack of oversight &to rush things out ASAP without much thought or consideration on actual execution and logistics of such recommended/allowed updates on mixing and matching vaccines. Is anyone else feel like things are getting out of hand on a retail level? I mean, at a 24 hour store, it does not help that people can schedule appointments online for ridiculous times like 1am, 2am, 5am, etc. Zero though was put into consideration in regards to waste management... Read more
The CDC is urging parents and guardians to vaccinate children aged 5 to 11 against COVID-19 once the shot is fully approved.WebMD Health News
At least 59,000 meatpacking workers caught COVID-19 and 269 workers died last year, which is significantly more than previously thought, according to a new US House report released Wednesday.Associated Press
"WHO Technical Advisory Group for Emergency Use Listing (EUL) is an independent advisory group that provides recommendations to WHO on whether a #COVID19 vaccine can be listed for emergency use under the EUL procedure," the WHO tweeted.
Local health care executives give their take on the Covid-19 pandemic and challenges they've faced.
Bogen said the county seemed to be in a slight decline but didn't want to declare that this latest delta-fueled wave of Covid was slowing down.
For more than a year now, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been causing the coronavirus disease (COVID-19) pandemic with high mortality and detrimental effects on society, economy, and individual lives. Great hopes are being placed on vaccination as one of the most potent escape strategies from the pandemic and multiple vaccines are already in clinical use. However, there is still a lot of insecurity about the safety and efficacy of vaccines in patients with autoimmune diseases like multiple sclerosis (MS), especially under treatment with immunomodulatory or immunosuppressive drugs. We propo...
Adv Exp Med Biol. 2021;1318:355-368. doi: 10.1007/978-3-030-63761-3_21.ABSTRACTDuring the COVID-19 pandemic associated with high incidence, transmissibility, and mortality, this chapter focuses on three phases of the disease: initial exposure, initiation of the immune response to the agent, and finally, an inflammatory/autoimmune-like presentation with pulmonary, neurological, and renal failure and disseminated intravascular coagulation which occurs in a small proportion of the patients. The elegant demonstration of the site of interaction between the spike (S) protein of the severe acute respiratory syndrome coronavirus 2...