Uterine leiomyomas in hereditary leiomyomatosis and renal cell cancer (HLRCC) syndrome can be identified through distinct clinical characteristics and typical morphology

ConclusionsWomen with HLRCC may be identified through the distinct clinical characteristics: symptomatic and numerous leioymyomas at young age, and morphologic features ofFH-mutant leiomyomas, aided by Bcl-2 and CD34 immunohistochemistry. Further, distinguishing individuals with a germlineFH mutation enables proper genetic counseling and regular renal monitoring.

Source: Acta Obstetricia et Gynecologica Scandinavica - September 4, 2021 Category: OBGYN Authors: Outi Uimari, Anne Ahtikoski, Kati K ämpjärvi, Ralf Butzow, Ilkka Y. Järvelä, Markku Ryynänen, Lauri A. Aaltonen, Pia Vahteristo, Outi Kuismin Tags: ORIGINAL RESEARCH ARTICLE Source Type: research