IJERPH, Vol. 18, Pages 9352: Antibiotic Susceptibility of Environmental Legionella pneumophila Strains Isolated in Northern Italy

In conclusion, this study has provided additional susceptibility data for environmental Legionella pneumophila isolates from Northern Italy demonstrating, in general, low MICs values for the tested antimicrobials, although one strain tested was shown to possess the LpeAB resistance determinant, indicating that future surveillance studies are warranted.
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research

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We present the case of an adolescent patient with pre-B-cell acute lymphoblastic leukemia (pre-B ALL) requiring ECMO support for septic shock and ARDS due to disseminated Legionella. To our knowledge, this is the first case describing an immunocompromised pediatric patient supported with ECMO for Legionnaires' disease.PMID:34658413 | PMC:PMC8499640 | DOI:10.1182/ject-2100020
Source: Journal of Extra-Corporeal Technology - Category: Cardiovascular & Thoracic Surgery Authors: Source Type: research
AbstractObjectiveTo investigate the results of real-world application of non-myeloablative autologous HSCT for multiple sclerosis (MS).MethodsBetween July 2003 and October 2019 at a single center (Northwestern University), 414 patients with relapsing remitting MS (RRMS) and 93 patients with newly diagnosed secondary progressive MS (SPMS) underwent non-myeloablative HSCT.ResultsThere was one treatment-related death (0.19%) due to hospital-acquired legionella pneumonia, and one patient developed neutropenic bacteremia (Klebsiella pneumonia) without sepsis. Overall 5-year survival was 98.8%. Post HSCT secondary autoimmune dis...
Source: Journal of Neurology - Category: Neurology Source Type: research
We report an acute clinical course of pneumonia caused byLegionella pneumophila in a patient receiving chemotherapy for lung cancer and corticosteroid therapy. A 57-year-old man presented with fever and dyspnoea and was admitted to our hospital. Chest computed tomography revealed a new left lower lung infiltrate, tumour progression in the right upper lung region, metastases to lymph nodes and pleural effusion. The urinary antigen test forLegionella was positive. The patient's oxygen requirement increased on the day of admission, and he died the day after hospitalization. Legionnaires' disease may manifest with an acute pre...
Source: Respirology Case Reports - Category: Respiratory Medicine Authors: Tags: CASE REPORT Source Type: research
CONCLUSIONS: The results showed that using the real-time PCR has a more efficacy for detecting of Legionella species in respiratory samples. Also, L. pneumophila was the most prevalent species circulating in the southwest region of Iran. So, periodic monitoring programs is recommended to prevent epidemics due to this bacterium.PMID:34618288 | DOI:10.1007/s11033-021-06704-3
Source: Molecular Biology Reports - Category: Molecular Biology Authors: Source Type: research
Legionella pneumophila is an opportunistic pathogen that causes the potentially fatal pneumonia known as Legionnaires' Disease. The pathology associated with infection depends on bacterial delivery of effector proteins into the host via the membrane spanning Dot/Icm type IV secretion system (T4SS). We have determined sub-3.0 Å resolution maps of the Dot/Icm T4SS core complex by single particle cryo-EM. The high-resolution structural analysis has allowed us to identify proteins encoded outside the Dot/Icm genetic locus that contribute to the core T4SS structure. We can also now define two distinct areas of symmetry mi...
Source: eLife - Category: Biomedical Science Tags: Microbiology and Infectious Disease Source Type: research
We describe a March 2020 co-occurrence of Legionnaires' disease (LD) and coronavirus disease in France. Severe acute respiratory syndrome coronavirus 2 co-infections were identified in 7 of 49 patients from LD case notifications. Most were elderly men with underlying conditions who had contracted severe pneumonia, illustrating the relevance of co-infection screening.PMID:34469708 | DOI:10.3201/eid2711.202150
Source: Emerging Infectious Diseases - Category: Infectious Diseases Authors: Source Type: research
Legionella pneumophila is an important pathogen and is involved in more than 95% of cases of severe atypical pneumonia. The current study focused on the ablution water in the grand mosque in Makkah as well as water tanks in hotels surrounding the holy mosque. A total of 100 water samples were collected from ablution water in the Haram and the hotels in the central area around the grand mosqu...
Source: African Journal of Microbiology Research - Category: Microbiology Source Type: research
Tidsskr Nor Laegeforen. 2021 Jun 28;141(11). doi: 10.4045/tidsskr.21.0092. Print 2021 Aug 17.ABSTRACTBACKGROUND: Most cases of legionellosis in Norway are acquired outside the country. This was a domestic case from an unusual source.CASE PRESENTATION: A man in his thirties was admitted with pneumonia early in the summer. He developed respiratory failure before recovering. Cultures from his lower airways grew Legionella pneumophila serogroup 1. Samples from his home and workplace did not identify Legionella. On further questioning it was discovered that the patient regularly sat beside an outdoor fountain during his breaks ...
Source: Tidsskrift for den Norske Laegeforening - Category: General Medicine Authors: Source Type: research
CONCLUSIONS: The patient had a favorable outcome with early diagnosis and early treatment of both diseases. Patients with severe COVID-19 disease need to be evaluated for co-infection. Further, early diagnosis and early treatment of the microbial bacteria causing the co-infection are important.PMID:34409491 | DOI:10.1186/s40981-021-00467-3
Source: Clinical Prostate Cancer - Category: Cancer & Oncology Authors: Source Type: research
This study aimed to evaluate its ecology and to identify this Legionella species as a respiratory pathogen. A PCR assay for detecting the L. feeleii mip gene was developed to identify it in clinical and environmental samples. Culture and PCR were performed in environmental samples from four drinking water treatment plants (DWTPs). Free L. feeleii was only detected in raw water samples (3.4%), while L. feeleii as an Acanthamoeba endosymbiont was found in 30.7% of raw water, 11.5% of decanter biofilm, and 32% of finished water samples. Therefore, Acanthamoeba spp. plays an essential role in the multiplication, persistence, a...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
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