Epigenetic alterations in prescription opioid misuse: new strategies for precision pain management - Gerra MC, Dallabona C, Arendt-Nielsen L.

Prescription opioids are used for some chronic pain conditions. However, generally, long-term therapy has unwanted side effects which may trigger addiction, overdose, and eventually cause deaths. Opioid addiction and chronic pain conditions have both been ...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

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ConclusionDespite being turned back from an effort to bluntly reduce opioid prescribing by the FDA in 2013 based on a lack of scientific evidence for its position (17,18), PROP has had a disproportionate effect on opioid policy in the Untied States for almost a decade. PROP found a willing federal regulatory partner in the CDC, and while PROP may not have “secretly written” the 2016 CDC Pain Guidelines (75), they certainly enjoyed disproportionate representation on CDC’s review panels and Core Expert Group (23-25) in a process that lacked transparency (22, 23, 26, 27). When the CDC admitted that its Pain ...
Source: Pallimed: A Hospice and Palliative Medicine Blog - Category: Palliative Care Tags: CDC health policy kollas opioids pain prop Source Type: blogs
We describe the historical use of opioids and the scope of the current opioid crisis, review the differences between dependence and addiction, and the private and public sectors response to pain management and highlight the issue of adolescent vulnerability. We conclude with a proposal for future directions that address both public and patient health needs.
Source: Current Opinion in Anaesthesiology - Category: Anesthesiology Tags: PEDIATRIC ANESTHESIA: Edited by Jorge A. Gálvez Source Type: research
Opioid Overdose: Signs, Symptoms, and What to Do Any individual who uses opioids runs the risk of overdosing. Overdoses can be fatal. In fact, more than 130 people in the United States die after overdosing on opioids every day. This makes it important to know what causes an opioid overdose, the signs that an opioid overdose is occurring, and what to do in the event of an opioid overdose. Opioid Overdose Causes In 2017, the CDC reported that more than 15,000 individuals died from drug overdoses involving heroin in the United States. That’s almost 5 deaths for every 100,000 Americans. However, there are some people who...
Source: Cliffside Malibu - Category: Addiction Authors: Tags: Detox Resources for Alcohol and Drugs/Opiates Painkiller drug overdose opiate addiction opioid opioids Source Type: blogs
The opioid crisis is known as the health crisis surrounding prescription, and nonprescription, opioid drugs. The overdose and death rates of opioids are climbing exponentially and the use of the drug is more rampant now than ever. How Did the Opioid Crisis Begin? In the late 1990s, pharmaceutical companies reassured the medical community that patients would not become addicted to prescription opioid pain relievers, and healthcare providers began to prescribe them at greater rates. Before long, this lead to the medications becoming misused and it became apparent that these medications were indeed highly addictive. However,...
Source: Cliffside Malibu - Category: Addiction Authors: Tags: Addiction Addiction to Pharmaceuticals Heroin Addiction Recovery opioid opioid crisis opioids pharmaceutical addiction pharmaceutical drug abuse treatment pharmacists Source Type: blogs
What is the Definition of “Opioid”? The definition of opioid is as follows: Opioids are a class of drugs that include the illegal drug heroin, synthetic opioids such as fentanyl, and pain relievers available legally by prescription, such as oxycodone, hydrocodone, codeine, morphine, and many others. Opioids work by interacting with the opioid receptors on nerve cells in the body and brain. By interacting with these receptors, opioids medications are able to cut off communication between the pain point on the body to the brain. This chemical interaction gives it’s users pain relief that is too great for ov...
Source: Cliffside Malibu - Category: Addiction Authors: Tags: Addiction to Pharmaceuticals fentanyl heroin heroin addiction opiate opiate abuse opiate addiction opiates opioid opioids Source Type: blogs
AbstractGlobally, chronic pain is a major therapeutic challenge and affects more than 15% of the population. As patients with painful terminal diseases may face unbearable pain, there is a need for more potent analgesics. Although opioid-based therapeutic agents received attention to manage severe pain, their adverse drug effects and mortality rate associated with opioids overdose are the major concerns. Evidences from clinical trials showed therapeutic benefits of cannabis, especially delta-9-tetrahydrocannabinol and cannabinoids reduced neuropathic pain intensity in various conditions. Also, there are reports on using co...
Source: Journal of Anesthesia - Category: Anesthesiology Source Type: research
Addiction is a chronic condition that leads to overdose and death. Addiction ruins lives, families and devastates communities. If you are suffering from addiction, it can be normal to ask yourself hard questions such as, “will I suffer from addiction forever? Is there a cure for addiction?” While there is no magic wand that can cure addiction, it is a treatable condition. When addiction is treated, people can go on to live normal, happy, healthy lives. While addiction may cause a lot of destruction and fractured relationships in its path, people can repair and move on from them as well. The Cure for Addiction:...
Source: Cliffside Malibu - Category: Addiction Authors: Tags: Addiction Addiction Recovery Complementary Therapies Comprehensive behavioral treatment Healthy Eating and Recovery Mental Health Sober Living and Aftercare Substance Abuse addicted to alcohol addiction help addiction recovery programs Source Type: blogs
BACKGROUND: In Canada, the rise in prescription opioid (PO) overdoses and addiction is a major public health concern. Various health authorities have recently recommended that physicians use caution when prescribing opioids, especially to people with histo...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
Ryan R. Kelly1,2†, Lindsay T. McDonald1,2†, Nathaniel R. Jensen1,2, Sara J. Sidles1,2 and Amanda C. LaRue1,2* 1Research Services, Ralph H. Johnson VA Medical Center, Charleston, SC, United States 2Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC, United States The significant biochemical and physiological effects of psychological stress are beginning to be recognized as exacerbating common diseases, including osteoporosis. This review discusses the current evidence for psychological stress-associated mental health disorders as risk factors for os...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
What is a Benzodiazepine? Benzodiazepines are a prescription drug sedative used to treat a variety of conditions. They are classified as Schedule IV in the Controlled Substances Act. Some of the conditions that Benzodiazepine can treat include: Insomnia Anxiety Seizures Muscle tension Panic disorders When used as prescribed under the supervision of a medical professional, Benzodiazepines can be very useful in the treatment of these disorders. Many people are able to live healthy, happy lives while taking Benzodiazepines to curb the symptoms of their various conditions. However, because of the addictive nature of Benzodia...
Source: Cliffside Malibu - Category: Addiction Authors: Tags: Uncategorized benzo benzodiazepines prescription drug abuse prescription drug addiction prescription drug use prescription pills Source Type: blogs
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