Protective effects of hydro-ethanolic leaf extract based formulation of Mucuna pruriens (Fabaceae) on phenylhydrazine induced hemolytic anemia and metabo-hematological alterations in rats

This study is aimed at evaluating the use ofMucuna pruriens herb in the treatment of hemolytic anemia secondary to malaria. Thirty-six adult male rats weighing between 150 and 200  g were divided into six groups (n = 6). Group I served as the negative control and received syrup formulation without the extract (placebo) but allowed access to food and water ad libitum. Groups II to VI received phenyl hydrazine 60 mg/kg for 3 days to induce anemia. Additionally, groups IV to VI received 50 mg/kg, 100 mg /kg, and 200 mg/kg ofMucuna pruriens syrup formulation respectively, while group III received a standard drug. Feed and water consumption were measured weekly while PCV, Hb, RBC, platelet, ESR, MCV, MCHC, MCH, WBC, lymphocytes, neutrophils, monocytes, eosinophils, and basophils were measured before anemia induction and at days 0, 7, 14, and 21. Phytochemical analysis of the extract was also carried out. Administration of phenylhydrazine significantly decreased (p 
Source: Comparative Clinical Pathology - Category: Pathology Source Type: research

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Am J Trop Med Hyg. 2021 Sep 27:tpmd200413. doi: 10.4269/ajtmh.20-0413. Online ahead of print.ABSTRACTIn malaria endemic countries, anemia in pregnant women occurs as a result of erythrocyte destruction by Plasmodium infections and other causes including malnutrition. Iron supplementation is recommended as treatment of iron-deficiency anemia. Erythrocyte destruction results in increased release of cytotoxic free heme that is scavenged by haptoglobin (Hp), hemopexin (Hx) and heme oxygenase-1 (HO-1). Paradoxically, iron supplementation in pregnant women has been reported to enhance parasitemia and increase levels of free heme...
Source: Am J Trop Med Hyg - Category: Infectious Diseases Authors: Source Type: research
Infect Genet Evol. 2021 Jul 17:105009. doi: 10.1016/j.meegid.2021.105009. Online ahead of print.ABSTRACTBACKGROUND: Increasing resistance of Plasmodium falciparum to sulfadoxine-pyrimethamine (SP) threatens its usefulness for intermittent preventive treatment in pregnancy (IPTp-SP). The prophylactic effects of IPTp-SP on maternal malaria and adverse pregnancy outcomes were evaluated in Kingasani Hospital, Kinshasa in the Democratic Republic of Congo (DRC).METHODS: Laboring women (n = 844) and respective newborns were investigated. Blood samples collected from women were tested for malaria using rapid diagnostic test (RDT),...
Source: Infection, Genetics and Evolution - Category: Genetics & Stem Cells Authors: Source Type: research
Infect Genet Evol. 2021 Jul 9:105000. doi: 10.1016/j.meegid.2021.105000. Online ahead of print.ABSTRACTPathophysiology of Plasmodium falciparum and Plasmodium vivax in malaria vis a vis host and the parasite genome interactions has been deciphered recently to present the biology of cerebral malaria, severe anaemia and placental malaria. Small non-coding RNAs have exhibited their potential to be considered as indicators and regulators of diseases. The malarial pathologies and their associated mechanisms mediated by miRNAs and their role in haematopoiesis and red cell-related disorders are elucidated. Evidence of miRNA carry...
Source: Infection, Genetics and Evolution - Category: Genetics & Stem Cells Authors: Source Type: research
Each year, more than 200 million cases of malaria occur worldwide, the majority in Africa [1]. Pregnant women and children older than 6 months of age are the most vulnerable groups affected by malaria. In fact, malaria in pregnancy is estimated to account for 100,000 neonatal deaths annually and it increases the risk of severe maternal anaemia, premature delivery, low birth weight (LBW) and perinatal mortality [2, 3]. The lower impact of malaria disease in infants younger than 6 months of age is thought to be due to a number of factors, such as passive transfer of maternal antibodies or higher presence of foetal haemoglobi...
Source: Journal of Infection - Category: Infectious Diseases Authors: Source Type: research
Conclusions: The comorbidity of malaria and intestinal helminths causes lower hemoglobin level leading to maternal anemia, preterm delivery, and still birth in pregnant women and lactating mother. School-aged children and neonates coinfected by plasmodium species and soil transmitted helminths develop cognitive impairment, protein energy malnutrition, low birth weight, small for gestational age, and gross motor delay. The Ministry of Health of Ethiopia and its international partners working on malaria elimination programs should give moreemphasis to the effect of the interface of malaria and soil transmitted helminths, whi...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Review Source Type: research
Pregnancy-associated malaria (PAM) caused by Plasmodium falciparum can result in detrimental outcomes for both mother and infant, including low infant birth weight, preterm birth, maternal anemia, spontaneous abortion, and maternal and/or infant mortality. Maternal anemia is a particularly complex outcome, as the body must both maintain erythropoiesis and tolerance of the growing fetus, while directing a Th1 response against the parasite. Underlying the pathogenesis of PAM is the expression of variant surface antigens (VSAPAM) on the surface of infected red blood cells (iRBC) that mediate sequestration of the iRBC in the p...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Abstract Artemisinin combination therapies are the current frontline therapy for falciparum malaria. Artemisinin is activated by heme iron, and the consequent production of reactive oxygen species and carbon-centered radicals results in rapid parasite clearance. Red blood cells (RBCs) from anemic iron-deficient individuals have decreased levels of heme, and such deficiencies are highly prevalent among children and pregnant women in malaria-endemic countries. We, therefore, investigated the possibility that host anemia could impair artemisinin activity and alter the drug sensitivity of artemisinin-resistant strains...
Source: The American Journal of Tropical Medicine and Hygiene - Category: Tropical Medicine Authors: Tags: Am J Trop Med Hyg Source Type: research
Authors: Gari W, Tsegaye A, Ketema T Abstract Anemia is one of the major causes of morbidity for pregnant women in resource-limited regions. Yet robust research-based evidence on this vital public health problem in remote areas where the problem could be massive is quite limited in Ethiopia, one of the developing countries. Thus, this study is aimed to assess the magnitude of anemia and its associated risk factors among pregnant women attending one of the health facilities in Ethiopia. A facility-based cross-sectional study design was employed in 2019. A total of 384 pregnant women attending the antenatal care (ANC...
Source: Anemia - Category: Hematology Tags: Anemia Source Type: research
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