New mediators in diabetes pathogenesis: exosomes and metabolites

AbstractType 2 diabetes is a systemic disorder characterized by metabolic impairment in multiple organs1. Various factors trigger insulin resistance in muscle, liver and adipose tissue resulting in increased insulin demand and de-repression of hepatic gluconeogenesis. When pancreatic β cells fail to compensate their mass and function to the increased insulin demand, β cell apoptosis and dedifferentiation occurs which leads to hyperglycemia.
Source: Journal of Diabetes Investigation - Category: Endocrinology Authors: Tags: EDITORIAL Source Type: research