Hemodynamic optimization for neonates with neonatal encephalopathy caused by a hypoxic ischemic event: Physiological and therapeutic considerations

Neonatal encephalopathy due to a hypoxic-ischemic event is commonly associated with cardiac dysfunction and acute pulmonary hypertension; both therapeutic hypothermia and rewarming modify loading conditions and blood flow. The pathophysiological contributors to disease are complex with a high degree of clinical overlap and traditional bedside measures used to assess circulatory adequacy have multiple confounders. Comprehensive, quantitative echocardiography may be used to delineate the relative contribution of lung parenchymal, pulmonary vascular, and cardiac disease to hypotension and/or hypoxemic respiratory failure.

Source: Seminars in Fetal and Neonatal Medicine - August 12, 2021 Category: Perinatology & Neonatology Authors: Danielle R. Rios, Anie Lapointe, Georg M. Schmolzer, Khorshid Mohammad, Krisa P. VanMeurs, Roberta L. Keller, Arvind Sehgal, Satyan Lakshminrusimha, Regan E. Giesinger, Newborn Brain Society Guidelines and Publications Committee Source Type: research