July 2021

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Source: NIH News in Health - Category: Consumer Health News Source Type: news

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Brain Behav Immun. 2022 Jan 19:S0889-1591(22)00018-6. doi: 10.1016/j.bbi.2022.01.015. Online ahead of print.ABSTRACTAutism spectrum disorder (ASD) is a complex neurodevelopmental condition caused by interactions of environmental and genetic factors. Recently we showed that activation of the purinergic P2X7 receptors is necessary and sufficient to convert maternal immune activation (MIA) to ASD-like features in male offspring mice. Our aim was to further substantiate these findings and identify downstream signaling pathways coupled to P2X7 upon MIA. Maternal treatment with the NLRP3 antagonist MCC950 and a neutralising IL-1...
Source: Brain, Behavior, and Immunity - Category: Neurology Authors: Source Type: research
Mol Psychiatry. 2022 Jan 21. doi: 10.1038/s41380-021-01433-2. Online ahead of print.NO ABSTRACTPMID:35064235 | DOI:10.1038/s41380-021-01433-2
Source: Molecular Medicine - Category: Molecular Biology Authors: Source Type: research
In conclusion, sevoflurane anesthesia in neonatal period could disturb development of social memory and impair preference for social novelty in female mice at early-adulthood, with the potential mechanism of decreasing PSD95 expression in the hippocampus of C57BL/6 mice.PMID:35063768 | DOI:10.1016/j.bbrc.2022.01.022
Source: Biochemical and Biophysical Research communications - Category: Biochemistry Authors: Source Type: research
J Autism Dev Disord. 2022 Jan 22. doi: 10.1007/s10803-022-05434-0. Online ahead of print.ABSTRACTGiven long waitlists for autism spectrum disorder (ASD) evaluation coupled with the COVID-19 pandemic, it is crucial to triage patients to services they are likely to receive diagnostic clarity (i.e., virtual, in-person evaluation). Participants attended a virtual ASD assessment. A subset also attended in-person evaluation. Results suggest younger children with educational services for ASD may benefit from virtual assessment while older patients with a history of psychiatric conditions may benefit from in-person evaluation. An ...
Source: Journal of Autism and Developmental Disorders - Category: Psychiatry Authors: Source Type: research
J Autism Dev Disord. 2022 Jan 22. doi: 10.1007/s10803-022-05442-0. Online ahead of print.ABSTRACTPrevious psychophysical studies reported a positive aftereffect in tactile temporal order judgments, which can be explained by the Bayesian estimation model ('Bayesian calibration'). We investigated the relationship between Bayesian calibration and autistic traits in participants with typical development (TD) and autism spectrum disorder (ASD). Bayesian calibration was weakened in TD participants with high autistic traits, consistent with the 'hypo-priors' hypothesis for autistic perceptions. The results from the ASD group were...
Source: Journal of Autism and Developmental Disorders - Category: Psychiatry Authors: Source Type: research
J Autism Dev Disord. 2022 Jan 22. doi: 10.1007/s10803-021-05405-x. Online ahead of print.ABSTRACTDespite increasing attention to understanding strengths in those on the autism spectrum, few studies have explored this in older individuals. The present study provides a qualitative analysis of parent-reported strengths and positive qualities of 68 15-30-year-olds with autism and/or intellectual disability (ID). Most parents (97%) reported at least one positive quality. Themes were consistent with previous studies; Personality characteristics (82%) and Sociability (53%) were reported most frequently. A Work Ethic/Motivation ca...
Source: Journal of Autism and Developmental Disorders - Category: Psychiatry Authors: Source Type: research
Source: Journal of Neurology - Category: Neurology Source Type: research
Genes, Vol. 13, Pages 199: “Silicon-On-Insulator”-Based Nanosensor for the Revelation of MicroRNA Markers of Autism Genes doi: 10.3390/genes13020199 Authors: Yuri D. Ivanov Kristina A. Malsagova Kristina V. Goldaeva Tatyana O. Pleshakova Ivan D. Shumov Rafael A. Galiullin Svetlana I. Kapustina Ivan Y. Iourov Svetlana G. Vorsanova Stepan V. Ryabtsev Vladimir P. Popov Alexander I. Archakov MicroRNAs (miRNAs), which represent short (20 to 22 nt) non-coding RNAs, were found to play a direct role in the development of autism in children. Herein, a highly sensitive “silicon-on-...
Source: Genes - Category: Genetics & Stem Cells Authors: Tags: Article Source Type: research
ConclusionsBorrelia infection in the setting of acute aortic pathology is a rare entity. To our knowledge, this is the first case report to demonstrate a mycotic abdominal aortic aneurysm as a rare manifestation of Lyme disease. Aortic wall biopsies and real-time polymerase chain reaction analysis of the specimen were essential for accurate diagnosis. This finding may contribute to the understanding of the etiology of inflammatory aneurysmal disease and abdominal aneurysms in general.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
ConclusionThis rat model of preterm WMI does not lead to long-term cognitive deficits as observed in prematurely born human infants.
Source: Psychopharmacology - Category: Psychiatry Source Type: research
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