Development of an Informatics Algorithm to Link Seasonal Infectious Diseases to Birth-Dependent Diseases Across Species: A Case Study with Osteosarcoma

AMIA Annu Symp Proc. 2021 May 17;2021:585-594. eCollection 2021.ABSTRACTMany diseases have been linked with birth seasonality, and these fall into four main categories: mental, cardiovascular, respiratory and women's reproductive health conditions. Informatics methods are needed to uncover seasonally varying infectious diseases that may be responsible for the increased birth month-dependent disease risk observed. We have developed a method to link seasonal infectious disease data from the USA to birth month dependent disease data from humans and canines. We also include seasonal air pollution and climate data to determine the seasonal factors most likely involved in the response. We test our method with osteosarcoma, a rare bone cancer. We found the Lyme disease incidence was the most strongly correlated significant factor in explaining the birth month-osteosarcoma disease pattern (R=0.418, p=2.80X10-23), and this was true across all populations observed: canines, pediatric, and adult populations.PMID:34457174 | PMC:PMC8378620
Source: AMIA Annual Symposium Proceedings - Category: Bioinformatics Authors: Source Type: research

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Contributors : King L Hung ; Kathryn E Yost ; Liangqi Xie ; Quanming Shi ; Konstantin Helmsauer ; Jens Luebeck ; Robert Sch öpflin ; Joshua T Lange ; Rocio Chamorro ; Natasha E Weiser ; Celine Chen ; Maria E Valieva ; Ivy Tsz-Lo Wong ; Sihan Wu ; Siavash R Dehkordi ; Connor V Duffy ; Katerina Kraft ; Jun Tang ; Julia A Belk ; John C Rose ; M R Corces ; Jeffrey M Granja ; Utkrisht Rajkumar ; Jordan Friedlein ; An indya Bagchi ; Ansuman T Satpathy ; Robert Tijan ; Stefan Mundlos ; Vineet Bafna ; Anton G Henssen ; Paul S Mischel ; Zhe Liu ; Howard Y ChangSeries Type : Expression profiling by high throughput sequencingOrg...
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New J. Chem., 2021, Advance Article DOI: 10.1039/D1NJ03038H, PaperMehmet Oguz, Berna Dogan, Serdar Durdagi, Asif Ali Bhatti, Serdar Karakurt, Mustafa Yilmaz Although quercetin is an effective bioactive compound preventing the progress of several human cancers, its impact is reduced due to low bioavailability. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - New J. Chem. latest articles - Category: Chemistry Authors: Source Type: research
AMIA Annu Symp Proc. 2021 May 17;2021:585-594. eCollection 2021.ABSTRACTMany diseases have been linked with birth seasonality, and these fall into four main categories: mental, cardiovascular, respiratory and women's reproductive health conditions. Informatics methods are needed to uncover seasonally varying infectious diseases that may be responsible for the increased birth month-dependent disease risk observed. We have developed a method to link seasonal infectious disease data from the USA to birth month dependent disease data from humans and canines. We also include seasonal air pollution and climate data to determine ...
Source: AMIA Annual Symposium Proceedings - Category: Bioinformatics Authors: Source Type: research
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