Phase I Trial of Stereotactic MRI-guided Online Adaptive Radiation Therapy (SMART) for the Treatment of Oligometastatic Ovarian Cancer

SBRT is increasingly used to treat a variety of oligometastatic histologies, but few data exist for ovarian cancer. Ablative SBRT dosing is challenging in sites like the abdomen, pelvis, and central thorax due to proximity and motion of organs-at-risk. A novel radiation delivery method, stereotactic magnetic-resonance-guided online-adaptive radiotherapy (SMART), may improve SBRT's therapeutic index through enhanced soft-tissue visualization, real-time non-ionizing imaging, and ability to adapt to the anatomy-of-the-day, with the goal of producing systemic-therapy-free intervals.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Clinical Investigation Source Type: research