COVID Vax Booster Trial Begun in People With Autoimmune Disease COVID Vax Booster Trial Begun in People With Autoimmune Disease

The trial will investigate the impact of a booster in patients with five autoimmune diseases who are either on or off immunosuppressives.Medscape Medical News
Source: Medscape Rheumatology Headlines - Category: Rheumatology Tags: Rheumatology News Source Type: news

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CONCLUSIONS: The results showed that the genetic algorithm improved the SVM classifier performance significantly implying the ability of the proposed model in terms of detecting relevant gene expression signatures as the best features.PMID:34540995 | PMC:PMC8443357 | DOI:10.1155/2021/5520710
Source: Biomed Res - Category: Research Authors: Source Type: research
J Clin Res Pediatr Endocrinol. 2021 Aug 18. doi: 10.4274/jcrpe.galenos.2021.2021.0139. Online ahead of print.ABSTRACTIt is well-known that in children with type 1 diabetes (T1D), the frequency of celiac disease (CD) is increased due to unclear mechanisms including autoimmune injury as well as shared genetic predisposition. Although histopathologic examination is gold standard, avoiding unnecessary endoscopy is crucial. Therefore, from the perspective of the clinicians and patients' families, the diagnosis of celiac disease remains challenging. With these in mind, a joint working group (Type 1 Diabetes and Celiac Disease Jo...
Source: JCRPE Journal of Clinical Research in Pediatric Endocrinology - Category: Endocrinology Authors: Source Type: research
Hypothesis: Autoimmune inner ear disease (AIED) patients will differentially express interleukin (IL)-6 based on corticosteroid responsiveness. Background: AIED is characterized by periods of acute sensorineural hearing loss (SNHL). In a majority of patients corticosteroid responsiveness is lost over time. The mechanisms that control corticosteroid responsiveness have not been fully elucidated. Methods: Thirty-five AIED patients and 13 age-matched control subjects were enrolled in this study. Steroid responsive (n = 15) and steroid nonresponsive AIED patients (n = 20) were characterized based on a...
Source: Otology and Neurotology - Category: ENT & OMF Tags: BASIC SCIENCE Source Type: research
Conclusions: There are no definite correlations to the COVID-19 pandemic or vaccination and new or worsened otologic symptoms. Vaccinated patients with new or exacerbated otologic symptoms should be promptly referred for evaluation. Suspected cases of post-vaccination otologic symptoms should be reported to the Center for Disease Control (CDC) vaccine adverse event reporting system (VAERS).
Source: Otology and Neurotology - Category: ENT & OMF Tags: SENSORINEURAL HEARING LOSS AND TINNITUS Source Type: research
Aceclofenac (ACE), a cyclooxygenase-2 inhibitor, is the derivative of the diclofenac group that has been in use for the symptomatic treatment of systemic inflammatory autoimmune disease, rheumatoid arthritis (RA). Partial solubility, high lipophilic nature, and stability challenge its use in developing topical formulations. Hence, we developed and characterized nanostructured lipid carrier (NLC)–based ACE (ACE-NLC) hydrogel for an efficient transdermal delivery. NLC microemulsion was prepared using different lipids by various methods and was characterized with respect to particle size, zeta potential, surface morphol...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Autoimmune diseases (AID) share various clinical signs and symptoms and pathophysiological mechanisms including the increased risk of cardiovascular disease. The coronary artery calcium score (CACS) is potentially useful in improving the cardiovascular risk assessment. The aim of this study was to evaluate the CACS in six AIDs analyzed as a group compared with controls through a systematic literature review (SLR) and meta-analysis.
Source: Atherosclerosis - Category: Cardiology Authors: Source Type: research
This study identified 31,923 patients who underwent ANA assay for SARDs screening, and a total of 1043 patients were included in the study. Approximately 16% of the patients showed a decrease in the serological ANA titer. Younger patients (  1:10,000 was associated with an increase likelihood of a decrease in the serological ANA titer compared with baseline ANA titer 1:10,000, 1:3200 and 1:1000 (P 
Source: Clinical and Experimental Medicine - Category: Research Source Type: research
Orv Hetil. 2021 Sep 19;162(38):1541-1547. doi: 10.1556/650.2021.32236.ABSTRACTÖsszefoglaló. A nekrotizáló sarcoid granulomatosis a granulomatosus pulmonalis angitisek közé tartozó, ritka kórkép. Egyesek a sarcoidosis variánsának, mások primer pulmonalis vasculitisnek tartják. A kórkép klinikai és patológiai jellegzetességeit két eset bemutatásával ismertetjük. A 20 éves nőbeteg sürgősséggel került pulmonológiai osztályra száraz k&o...
Source: Orvosi Hetilap - Category: General Medicine Authors: Source Type: research
Idiopathic inflammatory myopathies are a heterogenous group of diseases with prominent muscle inflammation and/or necrosis. Myositis is diagnosed through a combination of clinical, serologic, pathologic, and/or imaging findings, though these tools do not always yield clear diagnoses. A variety of neuromuscular conditions can mimic myositis, including muscular dystrophies, metabolic, endocrine, and toxic myopathies, and infectious myopathies. Through a series of four illustrative cases misdiagnosed as and treated for myositis, we highlight pitfalls and lessons to properly diagnosis myositis mimics to avoid immunosuppressant...
Source: Neuromuscular Disorders - Category: Neurology Authors: Source Type: research
The diagnosis of dermatomyositis had been relied on the combination of the typical skin lesions, perifascicular atrophy (PFA) and myositis. The discoveries of dermatomyositis-specific antibodies (DMSA i.e. TIF1- γ, Mi-2, MDA5, NXP2, and SAE) and type 1 interferon signature and its surrogate immunohistochemical marker, Myxovirus resistant protein A (MxA), in dermatomyositis has started the new era of the disease classification. We believe that dermatomyositis could be sero-pathologically defined using a com bination of DMSA and MxA.
Source: Neuromuscular Disorders - Category: Neurology Authors: Source Type: research
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