Galectin-7 promotes proliferation and wound healing capacities in periodontal ligament fibroblasts by activating ERK signaling

J Formos Med Assoc. 2021 Aug 25:S0929-6646(21)00390-9. doi: 10.1016/j.jfma.2021.08.014. Online ahead of print.ABSTRACTPeriodontitis is a progressive inflammation condition and a primary cause of tooth loss in adults. As one of the abundant cell types in the periodontium, periodontal ligament fibroblasts (PDLFs) play an integral role in the maintenance and regeneration of periodontal tissue. Our previous work has shown that the application of Er:YAG laser increased the cell proliferation and migratory capacity of PDLFs via induction of galectin-7. In the present study, we aimed to evaluate if the forced expression of galectin-7 directly affected the cellular phenotypes of PDLFs. Our results showed that the cell proliferation, transwell migration, invasion, and wound healing capacities were all upregulated in PDLFs with the ectopic expression of galectin-7. These results suggest that therapeutic approaches to enhance the expression of galectin-7 in periodontium may accelerate tissue regeneration by recruiting more PDLFs to the injured site.PMID:34452782 | DOI:10.1016/j.jfma.2021.08.014

Source: J Formos Med Assoc - August 28, 2021 Category: General Medicine Authors: Chao-Yen Huang Pei-Ling Hsieh Min Yee Ng Yi-Wen Liao Cheng-Chia Yu Taichen Lin Source Type: research