Diagnostic Performance of Hemophagocytic Lymphohistiocytosis Criteria and HScore in Critically Ill Patients With Severe Hemophagocytic Syndrome
OBJECTIVES:
To assess whether critically ill hematologic patients without diagnosis of hemophagocytic lymphohistiocytosis may have features mimicking hemophagocytic lymphohistiocytosis according to both diagnostic scores.
DESIGN:
A retrospective case-control study.
SETTING:
Hemophagocytic syndrome diagnosis was standardized and based on a consensual diagnosis by at least two experts of a university hospital which is a reference center for hemophagocytic syndrome.
PATIENTS:
Cases (hemophagocytic syndrome+) consisted in a group of consecutive patients (n = 150) admitted in our ICU between 2007 and 2018. Control group (hemophagocytic syndrome–) consisted in patients included in a prospective multicenter cohort of hematologic patients in whom three independent experts ruled out the diagnosis of hemophagocytic syndrome (n = 1011).
MEASUREMENTS AND MAIN RESULTS:
Overall, 1,161 patients were included. Hospital mortality was 45.8% in hemophagocytic syndrome– patients (n = 66) and 38.8% in control patients (n = 392; p = 0.126). Median HScore was 235 (205–262) in hemophagocytic syndrome+ and 42 (18–62) in hemophagocytic syndrome– patients (p
Source: Critical Care Medicine - Category: Emergency Medicine Tags: Online Brief Report Source Type: research