The role of complement in the tick cellular immune defense against the entomopathogenic fungus Metarhizium robertsii

Dev Comp Immunol. 2021 Aug 24:104234. doi: 10.1016/j.dci.2021.104234. Online ahead of print.ABSTRACTEntomopathogenic fungi (EPF) have been widely explored for their potential in the biological control of insect pests and as an environmentally friendly alternative to acaricides for limiting tick infestation in the field. The arthropod cuticle is the main barrier against fungal infection, however, an understanding of internal defense mechanisms after EPF intrusion into the invertebrate hemocoel is still rather limited. Using an infection model of the European Lyme borreliosis vector Ixodes ricinus with the EPF Metarhizium robertsii, we demonstrated that ticks are capable of protecting themselves to a certain extent against mild fungal infections. However, tick mortality dramatically increases when the capability of tick hemocytes to phagocytose fungal conidia is impaired. Using RNAi-mediated silencing of tick thioester-containing proteins (TEPs), followed by in vitro and/or in vivo phagocytic assays, we found that C3-like complement components and α2-macroglobulin pan-protease inhibitors secreted to the hemolymph play pivotal roles in M. robertsii phagocytosis.PMID:34450130 | DOI:10.1016/j.dci.2021.104234
Source: Developmental and Comparative Immunology - Category: Allergy & Immunology Authors: Source Type: research

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This post is in support of the CDC’s Fungal Disease Awareness Week — September 20-24, 2021. The impact of fungal diseases on human health has often been neglected, but increased association of fungal infections with severe illness and death during the COVID-19 pandemic has brought fungal diseases into the spotlight. According to the CDC, the … Continue reading Fungal Disease Awareness Week: fungal pathogen data and literature at NCBI →
Source: NCBI Insights - Category: Databases & Libraries Authors: Tags: What's New Assembly COVID-19 Fungi PubMed RefSeq Source Type: news
Teaching point: Meticulous anamnesis and a high index of suspicion is needed for the diagnosis of Lyme arthritis. Published on 2021-09-21 11:30:32
Source: Journal of the Belgian Society of Radiology - Category: Radiology Source Type: research
Emerg Infect Dis. 2021 Oct;27(10):2715-2717. doi: 10.3201/eid2710.210903.ABSTRACTSurveys indicate US residents spent more time outdoors in 2020 than in 2019, but fewer tick bite-related emergency department visits and Lyme disease laboratory tests were reported. Despite ongoing exposure, Lyme disease case reporting for 2020 might be artificially reduced due to coronavirus disease-associated changes in healthcare-seeking behavior.PMID:34545801 | DOI:10.3201/eid2710.210903
Source: Emerging Infectious Diseases - Category: Infectious Diseases Authors: Source Type: research
(Natural News) A majority of doctors in India say they would prescribe high doses of potent antibiotics to patients for different kinds of diseases, causing the rise of drug-resistant strains. The Wuhan coronavirus (COVID-19) pandemic revealed many hospitalized patients during the first wave with bacterial and fungal infections that antibiotics seemingly cannot cure. This added...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
Discussion Facial nerve palsy has been known for centuries, but in 1821 unilateral facial nerve paralysis was described by Sir Charles Bell. Bell’s palsy (BP) is a unilateral, acute facial paralysis that is clinically diagnosed after other etiologies have been excluded by appropriate history, physical examination and/or laboratory testing or imaging. Symptoms include abnormal movement of facial nerve. It can be associated with changes in facial sensation, hearing, taste or excessive tearing. The right and left sides are equally affected but bilateral BP is rare (0.3%). Paralysis can be complete or incomplete at prese...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
CONCLUSIONS: The EIDAR Research Area is responsive to military-relevant infectious disease threats that are also frequently global public health concerns. Several new EIDAR efforts are underway that will provide Combatant Command Surgeons, Infectious Diseases Service Chiefs, and other Force Health Protection stakeholders with epidemiological information to mitigate the impact of EIDs and antimicrobial resistance on the health of U.S. military service members and their dependents. PMID: 31004432 [PubMed - as supplied by publisher]
Source: Military Medicine - Category: International Medicine & Public Health Tags: Mil Med Source Type: research
Conclusions OCB are important biomarkers that can support MRI diagnostics and help to avoid false-positive MS diagnoses. Therefore, the revised McDonalds criteria have increased the importance of the OCB. New biomarkers such as AQP4 have now established themselves in clinical practice, and others such as Anti-MOG and NfL are about to enter clinical routine. An important focus in the search for new biomarkers is the monitoring of therapy efficacy and the prediction of severe side effects. Many other CSF molecules such as CHI3L1, IL-6, or CXCL13 show potential as markers for clinical practice, but further research is nee...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Conclusions:New-onset focal neurological deficits in immunocompromised patients with basal ganglia and cerebellar lesions may be infectious or neoplastic in etiology. Previously described pathogens associated with this presentation include Cryptoccocus, Candida, Toxoplasmosis, Mycobacterium, Coccidioides, Nocardia, and Listeria. Our case demonstrates unusual microbiology, with Klebsiella and Curvularia species as likely causative organisms. Awareness of these uncommon causes of CNS infection may allow for more prompt diagnosis and treatment.Disclosure: Dr. Das has nothing to disclose. Dr. Pohlen has nothing to disclose. Dr...
Source: Neurology - Category: Neurology Authors: Tags: Autoimmunity with Infection, Syphilis, Lyme, Tuberculosis, and other Bacteria Source Type: research
Conclusions:The current clinical observation serves to remind clinicians of the challenges faced in diagnosing brain ring-enhancing lesions, especially in patients with pre-existing brain disorders. Furthermore, it highlights the difficulty in treating invasive fungal infections in immunocompromised hosts. More studies are needed to establish the incidence and clinical course of invasive fungal infections in patients with sarcoidosis and infliximab therapy.Disclosure: Dr. Van Sanford has nothing to disclose. Dr. Obeidat has nothing to disclose. Dr. Zabeti has received personal compensation for activities with Biogen, Genzy...
Source: Neurology - Category: Neurology Authors: Tags: Autoimmunity with Infection, Syphilis, Lyme, Tuberculosis, and other Bacteria Source Type: research
Mepron, a thick liquid antimicrobial drug used to treat Babesia and malaria, as well as a fungal infection called Pneumocystitis carinii. In 2011, the United Kingdom stopped requiring that dogs brought into the country be inspected for ticks. Earlier this year, several dogs tested positive for babesia, a malaria-like disease transmitted to ticks that previously had only been found in foreign. These dogs had never left the U.K. While babesiosis is a new worry to U.K. dog owners, it's been a threat to human beings for years -- it just hasn't become a health-scare-of-the-week like Zika, West Nile, avian and swine flu. Most...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
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