State ‐of‐play for cellular therapies in cardiac repair and regeneration

Cardiovascular disease is the primary cause of death around the world. For almost two decades, cell therapy has been proposed as a solution for heart disease. In this article, we report on the “state-of-play” of cellular therapies for cardiac repair and regeneration. AbstractCardiovascular disease is the primary cause of death around the world. For almost two decades, cell therapy has been proposed as a solution for heart disease. In this article, we report on the “state-of-play” of cellular therapies for cardiac repair and regeneration. We outline the progression of new ideas from the preclinical literature to ongoing clinical trials. Recent data supporting the mechanics and mechanisms of myogenic and paracrine therapies are evaluated in the context of l ong-term cardiac engraftment. This discussion informs on promising new approaches to indicate future avenues for the field.

Source: Stem Cells - August 28, 2021 Category: Stem Cells Authors: Ramana Vaka, Darryl R. Davis Tags: CONCISE REVIEW Source Type: research