Mechanisms of Ethanol-Induced Cerebellar Ataxia: Underpinnings of Neuronal Death in the Cerebellum

Int J Environ Res Public Health. 2021 Aug 18;18(16):8678. doi: 10.3390/ijerph18168678.ABSTRACTEthanol consumption remains a major concern at a world scale in terms of transient or irreversible neurological consequences, with motor, cognitive, or social consequences. Cerebellum is particularly vulnerable to ethanol, both during development and at the adult stage. In adults, chronic alcoholism elicits, in particular, cerebellar vermis atrophy, the anterior lobe of the cerebellum being highly vulnerable. Alcohol-dependent patients develop gait ataxia and lower limb postural tremor. Prenatal exposure to ethanol causes fetal alcohol spectrum disorder (FASD), characterized by permanent congenital disabilities in both motor and cognitive domains, including deficits in general intelligence, attention, executive function, language, memory, visual perception, and communication/social skills. Children with FASD show volume deficits in the anterior lobules related to sensorimotor functions (Lobules I, II, IV, V, and VI), and lobules related to cognitive functions (Crus II and Lobule VIIB). Various mechanisms underlie ethanol-induced cell death, with oxidative stress and endoplasmic reticulum (ER) stress being the main pro-apoptotic mechanisms in alcohol abuse and FASD. Oxidative and ER stresses are induced by thiamine deficiency, especially in alcohol abuse, and are exacerbated by neuroinflammation, particularly in fetal ethanol exposure. Furthermore, exposure to ethanol during the prena...
Source: Cell Research - Category: Cytology Authors: Source Type: research

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Background: Survivors of bacterial meningitis (BM) often suffer from impaired quality of life that stems from disabling sequelae. The authors aimed to estimate health-related quality of life (HRQOL) and the influence of neurologic and audiologic sequelae among pediatric BM survivors. Methods: Survivors of 2 BM treatment trials at Luanda Children’s Hospital, Angola were evaluated for severity of disability via the modified Glasgow Outcome Scale, which considers neurologic and audiologic sequelae. Children who received vaccinations at the hospital during the time of the study (1–2, 2017) and survivors&...
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Original Studies Source Type: research
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Source: Tizard Learning Disability Review - Category: Disability Authors: Source Type: research
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Source: Tizard Learning Disability Review - Category: Disability Authors: Source Type: research
Walter OlsonWhen may the government fire or discipline public employees for off ‐​the‐​job speech? Salvatore Davi is a hearing officer at a New York state agency that hears appeals of welfare claims. In a private Facebook discussion Davi made comments critical of permanent welfare dependency and argued that a public safety net should be intended to help people regain self ‐​sufficiency. These comments offended another member of the group, who complained to Davi’s employer and leaked a copy of his comments to a legal activist group representing welfare recipients.Under the Fir...
Source: Cato-at-liberty - Category: American Health Authors: Source Type: blogs
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Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news
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Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news
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Source: SafetyLit - Category: International Medicine & Public Health Tags: Suicide and Self-Harm Source Type: news
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Source: UNISON Health care news - Category: UK Health Authors: Tags: Article further education Source Type: news
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Source: Healthcare News - Category: Pharmaceuticals Authors: Tags: Policy /policy Business /business Innovation /innovation Healthcare /healthcare sallypipesblog Source Type: news
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Source: Journal of Pediatric Orthopaedics - Category: Orthopaedics Tags: Sports Medicine Source Type: research
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