Left Atrial Strain and Compliance Correlate with Diastolic Dysfunction Grades and Complications during Pre-eclampsia: A Speckle-Tracking Echocardiography Study

This study aimed to investigate left atrium (LA) strain components in the assessment of cardiac function and its clinical correlates in pre-eclampsia (PE). With the use of speckle tracking echocardiography, phasic LA strain and (LASr)/(E/e'), the surrogate of LA compliance, were compared between healthy pregnant women (n  = 70) and those with PE (n = 146) and among different diastolic dysfunction (DD) grades in PE. Receiver operating characteristic curves and logistic regression analysis were used to identify the role of strain components in distinguishing DD grades and predicting cardiac complications.
Source: Ultrasound in Medicine and Biology - Category: Radiology Authors: Tags: Original Contribution Source Type: research

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AbstractStudy questionAre women presenting with bleeding in the first trimester of pregnancy at a higher risk for perinatal complications later in pregnancy?Summary answerWomen presenting with bleeding in the first trimester of pregnancy are more likely to experience perinatal and neonatal morbidity in pregnancy.What is known alreadyObservational studies and a previously reported systematic review showed that women who experienced threatened miscarriage are more likely to have still birth, intra uterine growth restriction (IUGR), low birth weight, pre-eclampsia, placental abruption, placenta previa, preterm labour, preterm...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research
Ultrasound Obstet Gynecol. 2021 Jul 28. doi: 10.1002/uog.23741. Online ahead of print.ABSTRACTOBJECTIVE: Evaluate the effect of first trimester combined Fetal Medicine Foundation (FMF) based pre-eclampsia screening on rates of fetal small for gestational age (SGA) birth and adverse pregnancy outcome.METHODS: A retrospective cohort study in a London tertiary hospital between January 2017 to March 2019. Secondary analysis of first trimester screening for pre-eclampsia: 7720 screened according to NICE risk-based approach and 4841 by FMF multimodal approach combining risk factors, blood pressure, PAPP-A and uterine Doppler ind...
Source: The Ultrasound Review of Obstetrics and Gynecology - Category: Radiology Authors: Source Type: research
Ultrasound Obstet Gynecol. 2021 Jun 24. doi: 10.1002/uog.23711. Online ahead of print.ABSTRACTBACKGROUND: Even though the most recent guidance by the International Society for the Study of Hypertension in Pregnancy (ISSHP) has highlighted the role of angiogenic markers in the diagnosis of preeclampsia in women with chronic hypertension, it has withheld recommending its implementation due to the limited available evidence in this group of women. Therefore, we aimed to evaluate sFlt-1 (soluble fms like kinase 1) and PlGF (placental growth factor) in women with suspected superimposed preeclampsia.METHODS: The study included 1...
Source: The Ultrasound Review of Obstetrics and Gynecology - Category: Radiology Authors: Source Type: research
Ultrasound Obstet Gynecol. 2021 May 16. doi: 10.1002/uog.23668. Online ahead of print.ABSTRACTOBJECTIVE: To examine the possible risk factors amongst maternal characteristics, medical and obstetric history, preeclampsia-specific biomarkers and estimated risks that relate to development of preterm preeclampsia despite aspirin prophylaxis.METHODS: This was a secondary analysis of data from the ASPRE trial. The study population consisted of women with singleton pregnancies who were deemed high-risk for preterm preeclampsia based on the Fetal Medicine Foundation algorithm that combines maternal factors, mean arterial pressure,...
Source: The Ultrasound Review of Obstetrics and Gynecology - Category: Radiology Authors: Source Type: research
Ultrasound Obstet Gynecol. 2021 May 16. doi: 10.1002/uog.23669. Online ahead of print.ABSTRACTOBJECTIVE: To compare the screening performance of serum pregnancy-associated plasma protein-A (PAPP-A) versus placental growth factor (PlGF) in routine first trimester combined screening for preeclampsia (PE), small for gestational age (SGA) birth and trisomy 21.METHODS: Retrospective study nested in pregnancy cohorts undergoing first trimester combined screening for PE and trisomy 21 using the Fetal Medicine Foundation (FMF) algorithm based on maternal characteristics, nuchal translucency, PAPP-A, free beta-human chorionic gonad...
Source: The Ultrasound Review of Obstetrics and Gynecology - Category: Radiology Authors: Source Type: research
Ultrasound Obstet Gynecol. 2021 May 16. doi: 10.1002/uog.23668. Online ahead of print.ABSTRACTOBJECTIVE: To examine the possible risk factors amongst maternal characteristics, medical and obstetric history, preeclampsia-specific biomarkers and estimated risks that relate to development of preterm preeclampsia despite aspirin prophylaxis.METHODS: This was a secondary analysis of data from the ASPRE trial. The study population consisted of women with singleton pregnancies who were deemed high-risk for preterm preeclampsia based on the Fetal Medicine Foundation algorithm that combines maternal factors, mean arterial pressure,...
Source: The Ultrasound Review of Obstetrics and Gynecology - Category: Radiology Authors: Source Type: research
Ultrasound Obstet Gynecol. 2021 May 16. doi: 10.1002/uog.23669. Online ahead of print.ABSTRACTOBJECTIVE: To compare the screening performance of serum pregnancy-associated plasma protein-A (PAPP-A) versus placental growth factor (PlGF) in routine first trimester combined screening for preeclampsia (PE), small for gestational age (SGA) birth and trisomy 21.METHODS: Retrospective study nested in pregnancy cohorts undergoing first trimester combined screening for PE and trisomy 21 using the Fetal Medicine Foundation (FMF) algorithm based on maternal characteristics, nuchal translucency, PAPP-A, free beta-human chorionic gonad...
Source: The Ultrasound Review of Obstetrics and Gynecology - Category: Radiology Authors: Source Type: research
AbstractBackground/Aims Disease activity of rheumatoid arthritis (RA) improves in around 60% of patients during pregnancy, but the mechanisms underlying this phenomenon remain unclear. T regulatory cells (Tregs) expressing the transcription factor FOXP3 serve to suppress inflammation and are known to play an important r ole in RA pathogenesis. These cells are also essential for the regulation of fetomaternal tolerance in pregnancy and protect against adverse pregnancy outcomes such as pre-eclampsia. Treg expansion in the third trimester of pregnancy has been associated with disease amelioration of RA. Therefore, we ex...
Source: Rheumatology - Category: Rheumatology Source Type: research
Ultrasound Obstet Gynecol. 2021 Apr 5. doi: 10.1002/uog.23645. Online ahead of print.ABSTRACTOBJECTIVES: To evaluate the performance of screening strategy for preterm preeclampsia using the Fetal Medicine Foundation (FMF)'s competing risk model in mainland China and to explore its clinical applicability.METHODS: A prospective multicenter study was conducted and 10,899 singleton pregnancies were included, Mean arterial pressure (MAP), uterine artery pulsatility index (UtPI), maternal serum levels of placental growth factor (PlGF) and pregnancy associated plasma protein A (PAPPA) at 11-13 weeks' gestation were measured and c...
Source: The Ultrasound Review of Obstetrics and Gynecology - Category: Radiology Authors: Source Type: research
The objective of this study is to examine the potential improvement in screening for PE with delivery at
Source: The Ultrasound Review of Obstetrics and Gynecology - Category: Radiology Authors: Source Type: research
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