How 3D Printing Could End The Deadly Shortage Of Donor Organs
Three-dimensional printing has been used to make everything from pizza to prostheses, and now researchers are working on using the emerging technology to fabricate hearts, kidneys, and other vital human organs. That would be very big news, as the number of people who desperately need an organ transplant far outstrips the number of donor organs available. On average, about 21 Americans die every day because a needed organ was unavailable. What exactly is the promise of 3D printing organs and tissues, or "bioprinting?" How does the technology work, and when might it start saving lives? For answers to these and other questions, HuffPost Science reached out to Dr. Anthony Atala (right), director of the Wake Forest Institute for Regenerative Medicine and a world-renowned expert in the field, to find out. See below for a lightly edited version of the Q &A. Can 3D printing end the shortage of organs? 3D printing is not magic. It is simply a way to scale up the current processes we use to engineer organs in the laboratory. Our team has successfully engineered bladders, cartilage, skin, urine tubes and vaginas that have been implanted in patients. Our goal is produce organ structures such as these with 3D printing to make the engineering process more precise and reproducible. The ultimate goal of regenerative medicine -– regardless of the way the organs are engineered -- is to help solve the shortage of donor organs. How might 3D-printed organs compare ...
Publication date: July 2018 Source:European Urology Supplements, Volume 17, Issue 5 Author(s): K. Čekas, H. Ramonas
Condition: Kidney Transplant Intervention: Drug: Immunosuppressive Sponsor: Chiesi Farmaceutici S.p.A. Not yet recruiting
Publication date: Available online 14 June 2018 Source:The Lancet Author(s): Gemma D Banham, Shaun M Flint, Nicholas Torpey, Paul A Lyons, Don N Shanahan, Adele Gibson, Christopher J E Watson, Ann-Marie O'Sullivan, Joseph A Chadwick, Katie E Foster, Rachel B Jones, Luke R Devey, Anna Richards, Lars-Peter Erwig, Caroline O Savage, Kenneth G C Smith, Robert B Henderson, Menna R Clatworthy Background B cells produce alloantibodies and activate alloreactive T cells, negatively affecting kidney transplant survival. By contrast, regulatory B cells are associated with transplant tolerance. Immunotherapies are needed that inhibit...
CONCLUSIONS 18F-FDG uptake by the WH and MDS tended to reduce after renal transplantation. Therefore, renal transplantation may confer an anti-inflammatory effect on carotid atherosclerosis in patients with CKD; however, this effect is not large enough to be demonstrated in this study with small sample size. PMID: 29904040 [PubMed - in process]
Norberto Perico, Federica Casiraghi, Marta Todeschini, Monica Cortinovis, Eliana Gotti, Valentina Portalupi, Marilena Mister, Flavio Gaspari, Alessandro Villa, Sonia Fiori, Martino Introna, Elena Longhi, Giuseppe Remuzzi
Authors: Herrero JI, Cuervas-Mons V, Gómez-Bravo MÁ, Fabregat J, Otero A, Bilbao I, Salcedo MM, González-Diéguez ML, Fernández JR, Serrano MT, Jiménez M, Rodrigo JM, Narváez I, Sánchez G Abstract INTRODUCTION: chronic kidney disease is a frequent complication after liver transplantation. The use of calcineurin inhibitors is one of the causes of this complication. Current immunsuppression regimens that reduce the use of calcineurin inhibitors may be associated with an improved preservation of renal function. OBJECTIVE: the study aimed to assess the evolutio...
CONCLUSION: The underlying mechanism is neither caused by infection nor fully explained by liver cell death alone and remains to be determined. PMID: 29893707 [PubMed - in process]
[Guardian] Life has never been the same for Omonjeva Helen Aseguahi since she was diagnosed with kidney disease. Aseguahi, an officer of the Young Christian Workers Movement (YCW), Isolo Deanery of the Catholic Church, Lagos, has since last year been down but battling to keep hope alive. Her only hope of getting a new lease of life is a kidney transplant, costing over N8 million.
The implant is expected to begin trials later this year and if successful, it could be available within a few years, saving patients from dialysis or needing a transplant.
We describe a case of a 46-year-old woman with 2 transplant kidneys, one functioning and another nonfunctioning, presenting with pelvic pain after a bilateral periureteral bulking procedure. Diuretic renography was performed to exclude iatrogenic ureteral obstruction. This showed a normally functioning transplant kidney without obstruction and subsequent vesicoureteral reflux into the collecting system of the nonfunctioning transplant kidney. This inadvertent indirect nuclear cystogram illustrates an unusual imaging presentation of a common disease process requiring further treatment.
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