How 3D Printing Could End The Deadly Shortage Of Donor Organs

Three-dimensional printing has been used to make everything from pizza to prostheses, and now researchers are working on using the emerging technology to fabricate hearts, kidneys, and other vital human organs. That would be very big news, as the number of people who desperately need an organ transplant far outstrips the number of donor organs available. On average, about 21 Americans die every day because a needed organ was unavailable. What exactly is the promise of 3D printing organs and tissues, or "bioprinting?" How does the technology work, and when might it start saving lives? For answers to these and other questions, HuffPost Science reached out to Dr. Anthony Atala (right), director of the Wake Forest Institute for Regenerative Medicine and a world-renowned expert in the field, to find out. See below for a lightly edited version of the Q &A. Can 3D printing end the shortage of organs? 3D printing is not magic. It is simply a way to scale up the current processes we use to engineer organs in the laboratory. Our team has successfully engineered bladders, cartilage, skin, urine tubes and vaginas that have been implanted in patients. Our goal is produce organ structures such as these with 3D printing to make the engineering process more precise and reproducible. The ultimate goal of regenerative medicine -– regardless of the way the organs are engineered -- is to help solve the shortage of donor organs. How might 3D-printed organs compare ...
Source: Science - The Huffington Post - Category: Science Source Type: news

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Conclusion The intrarenal RAS is activated in kidney transplant donors immediately after kidney donation, independent of the systemic BP and filtration of increased plasma AGT, due to augmented inflammation. PMID: 30333423 [PubMed - as supplied by publisher]
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
D. Possee Linda A. King Pancreatic islet transplantation is a promising treatment for type 1 diabetes mellitus offering improved glycaemic control by restoring insulin production. Improved human pancreatic islet isolation has led to higher islet transplantation success. However, as many as 50% of islets are lost after transplantation due to immune responses and cellular injury, gene therapy presents a novel strategy to protect pancreatic islets for improved survival post-transplantation. To date, most of the vectors used in clinical trials and gene therapy studies have been derived from mammalian viruses such as ade...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
Publication date: November 2018Source: American Journal of Kidney Diseases, Volume 72, Issue 5, Supplement 1Author(s): Marva Moxey-MimsPediatric-onset chronic kidney disease (CKD) is as relevant to adults as it is to children. Congenital anomalies of the kidney and urinary tract may have a significant impact on health from birth or during childhood or may not manifest until adulthood. Many acquired kidney diseases start to appear in late childhood and adolescence. The propensity for more rapid progression of CKD to end-stage kidney disease in adults of African ancestry, as well as disparities in access to kidney transplant...
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research
We present key clinical data, including a granular patient-level analysis of the associations of antiretroviral therapy regimens with long-term survival, cellular and antibody-mediated rejection rates, and the causes of allograft failures. In summary, we provide details on the evolution of our approach to HIV transplantation during the last 16 years, including strategies that may improve outcomes among HIV-positive kidney transplantation candidates throughout the United States.
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research
Monogenic forms of Steroid-Resistant Nephrotic Syndrome (SRNS) have been widely characterized, but genetic screening paradigms preferentially address congenital, infantile onset, and familial cases. Our aim was to characterize the distribution of disease-causing gene mutations in adults with sporadic SRNS or focal segmental glomerulosclerosis (FSGS). We selected adult patients with non-syndromic, biopsy-proven FSGS or SRNS in the absence of known family history. Strict clinical criteria included lack of response to glucocorticoids and cyclosporine, and no recurrence after kidney transplantation.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Clinical Investigation Source Type: research
Short-term renal allograft survival has improved more quickly than long-term outcomes. Analysis of more than 100,000 deceased donor renal transplants in Europe from 1986 to 2015 identified a declining rate of improvement in 1-year, death-censored graft survival but a continued improvement in longer-term survival, with a year-on-year 3% reduction in the risk of graft failure. These reassuring observations likely reflect improved overall transplant management rather than specific advances.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Commentary Source Type: research
International Journal of Rheumatic Diseases, EarlyView.
Source: APLAR Journal of Rheumatology - Category: Rheumatology Authors: Source Type: research
Abstract Several investigators performing bone marrow transplantation studies have previously reported sporadic increases in mortality that were associated with pronounced swelling in the face, head and neck of mice. Over the past few years, we and others have noted an increasing number of experiments in which mice that have received total-body irradiation (TBI) or partial-body irradiation (PBI) develop swollen muzzles, drastic thickening of the upper lip and redness, bruising and/or swelling around the nose and muzzle and sometimes over the top of the head. We refer to this rapid and extreme swelling after irradi...
Source: Radiation Research - Category: Physics Authors: Tags: Radiat Res Source Type: research
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis causes end-stage renal failure in up to a third of cases even with treatment. The disease recurs occasionally after kidney transplantation, but...
Source: BMC Nephrology - Category: Urology & Nephrology Authors: Tags: Case report Source Type: research
Abstract Kidney diseases including acute kidney injury and chronic kidney disease are among the largest health issues worldwide. Dialysis and kidney transplantation can replace a significant portion of renal function, however these treatments still have limitations. To overcome these shortcomings, a variety of innovative efforts have been introduced, including cell-based therapies. During the past decades, advances have been made in the stem cell and developmental biology, and tissue engineering. As part of such efforts, studies on renal cell therapy and artificial kidney developments have been conducted, and mult...
Source: Yonsei Medical Journal - Category: Universities & Medical Training Authors: Tags: Yonsei Med J Source Type: research
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