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How 3D Printing Could End The Deadly Shortage Of Donor Organs

Three-dimensional printing has been used to make everything from pizza to prostheses, and now researchers are working on using the emerging technology to fabricate hearts, kidneys, and other vital human organs. That would be very big news, as the number of people who desperately need an organ transplant far outstrips the number of donor organs available. On average, about 21 Americans die every day because a needed organ was unavailable. What exactly is the promise of 3D printing organs and tissues, or "bioprinting?" How does the technology work, and when might it start saving lives? For answers to these and other questions, HuffPost Science reached out to Dr. Anthony Atala (right), director of the Wake Forest Institute for Regenerative Medicine and a world-renowned expert in the field, to find out. See below for a lightly edited version of the Q &A. Can 3D printing end the shortage of organs? 3D printing is not magic. It is simply a way to scale up the current processes we use to engineer organs in the laboratory. Our team has successfully engineered bladders, cartilage, skin, urine tubes and vaginas that have been implanted in patients. Our goal is produce organ structures such as these with 3D printing to make the engineering process more precise and reproducible. The ultimate goal of regenerative medicine -– regardless of the way the organs are engineered -- is to help solve the shortage of donor organs. How might 3D-printed organs compare ...
Source: Science - The Huffington Post - Category: Science Source Type: news

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This editorial describes a patient who was cared for by the author. The patient developed end-stage kidney disease in the United States at the age of 17 but was denied kidney transplantation due to lack of insurance because of her immigration status. With the enactment of the Deferred Action for Childhood Arrivals (DACA) program, the patient was able to obtain a job and health insurance. The patient then received a kidney transplant when she was 27 years, after undergoing peritoneal dialysis for 10 years. The editorial describes how the DACA program improves the care of undocumented immigrants to the United States who are ...
Source: Nephron - Category: Urology & Nephrology Source Type: research
We present two cases of renal transplant patients who had severe hypoxemic respiratory failure due to P. jirovecii six years after transplantation. In addition to steroids, they received treatment with trimethoprim-sulfamethoxazole. One patient died, while the other had clinical recovery, with preservation of the renal graft function. PMID: 29668131 [PubMed - in process]
Source: Biomedica : Revista del Instituto Nacional de Salud - Category: International Medicine & Public Health Tags: Biomedica Source Type: research
A 44-year-old male patient presented with recurrent urinary tract infections (urine cultures negative) for 2 years. He was diagnosed as having a urethral stricture, and he underwent dilatations. However, his renal functions deteriorated, and he developed chronic kidney disease (CKD) requiring dialysis and transplantation. Pretransplant workup revealed 4 –5 leukocytes on urine examination, proteinuria (0.2 g/d), and a serum creatinine level of 6.7 mg/dl. Magnetic resonance imaging of his kidneys showed multifocal hyperintense lesions in both.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Nephrology Image Source Type: research
We thank Fusaro and her colleagues for their comments.1 We concur that there is a sound need for large, well-designed clinical studies to assess the prevalence, risk factors, treatment, and outcome of vertebral fractures in patients with chronic kidney disease (CKD). In our review,2 we did not include quantitative vertebral morphology as assessed by MorphoXpress software to quantify vertebral fractures in CKD. The assessment of vertebral fractures by quantitative vertebral morphology in patients on dialysis and renal transplant recipients resulted in the validation of the tool in osteoporotic patients of the general popula...
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Letter to the Editor Source Type: research
It is well recognized that the shortage of available kidneys has resulted in long wait times for dialysis patients seeking transplantation and that many patients die before receiving an allograft. Yet, the data presented by Reese et  al.,1 in their early, thoughtful proposal to begin considering transplanting hepatitis C virus (HCV)–positive kidneys, reveal that in the United States between 2005 and 2014, 4144 kidneys from 3273 deceased donors with hepatitis C antibody were discarded. With the recent development of highly ef fective, well-tolerated oral agents to treat HCV infection, it would seem desirable to t...
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Letter to the Editor Source Type: research
(Mayo Clinic) When patients undergo a dual kidney-liver transplant, the liver has a protective effect on the kidney, the study found.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
ConclusionsPreoperative PAPi and RAP strongly predict the development of AKI early after HTx and can be used as early AKI predictors.
Source: Intensive Care Medicine - Category: Intensive Care Source Type: research
American Journal of Transplantation, EarlyView.
Source: American Journal of Transplantation - Category: Transplant Surgery Authors: Source Type: research
(LONDON) — In a medical first, a French surgeon says he has performed a second face transplant on the same patient — who is now doing well and even spent a recent weekend in Brittany. Dr. Laurent Lantieri of the Georges Pompidou hospital in Paris first transplanted a new face onto Jerome Hamon in 2010, when Hamon was in his mid-30s. But after getting ill in 2015, Hamon was given drugs that interfered with the anti-rejection medicines he was taking for his face transplant. Last November, the tissue in his transplanted face began to die, leading Lantieri to remove it. That left Hamon without a face, a condition ...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized healthytime onetime Surgery Source Type: news
Condition:   Hiv Intervention:   Other: HIV D+/R+ Sponsors:   Johns Hopkins University;   National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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