Tadalafil and bergapten mitigate streptozotocin-induced sporadic Alzheimer's disease in mice via modulating neuroinflammation, PI3K/Akt, Wnt/ β-catenin, AMPK/mTOR signaling pathways

In conclusion, this study offers novel insights on the neuroprotective effects of TAD or BG in the management of SAD as evidenced by improved cognitive function and histological architecture. This could be attributed to modulation of the crosstalk among PI3K/Akt/GSK-3β, PP2A, mTOR/autophagy, cGMP/PKG, and Wnt/β-catenin signaling cascades and mitigation of neuroinflammation.PMID:34428446 | DOI:10.1016/j.taap.2021.115697

Source: Toxicology and Applied Pharmacology - August 24, 2021 Category: Toxicology Authors: Mohamed A Salem Barbara Budzy ńska Joanna Kowalczyk Nesrine S El Sayed Suzan M Mansour Source Type: research