Issue Information

We present biochemical, proteomic, and electron microscopy evidence that support the influence of Tnik on Arc neurobiology by modifying its nuclear trafficking or oligomerization as virus-like capsids. These findings suggest new ways about how phosphorylation can shape the temporal and spatial regulation of Arc within neurons.Image content: Negative electron microscopy image shows bacterially expressed Arc protein forming virus-like double layered capsids.Read the full article ‘Phosphorylation-dependent control of Activity-regulated cytoskeleton-associated protein (Arc) protein by TNIK’ by A. Walczyk-Mooradally, J. Holborn, K. Singh, M. Tyler, D. Patnaik, H. Wesseling, N. J. Brandon, J. Steen, S. P. Graether, S. J. Haggarty and J. Lalonde (J. Neurochem. 2021, vol. 158 (5), pp. 1058 –1073) on doi:10.1111/jnc.15440
Source: Journal of Neurochemistry - Category: Neuroscience Tags: Issue Information Source Type: research