A genome-wide cross-trait analysis highlights the shared genetic structure between COVID-19 and Alzheimer's disease

We read with interest the recently published research in Journal of Infection by Dr. Yang et al., who reported the higher mortality of COVID-19 patients with dementia compared with COVID-19 patients without dementia (effect estimate  = 1.84, 95% CI: 1.57–2.16) (1). Meanwhile, patients recovering from COVID-19 had a more severe burden of cognitive impairment, suggesting the potential risk of Alzheimer's disease (2). Although growing evidences indicate the potential genetic overlap between Alzheimer's disease and COVID-19, the genetic association degree and the shared genetic structure region between the two diseases remain unknown (3).
Source: Journal of Infection - Category: Infectious Diseases Authors: Source Type: research