Lipoprotein(a) in hereditary hypercholesterolemia: Influence of the genetic cause, defective gene and type of mutation

Lipoprotein(a) [Lp(a)] concentration in heterozygous familial hypercholesterolemia (heFH) is not well established. Whether the genetic defect responsible for heFH plays a role in Lp(a) concentration is unknown.We aimed to compare Lp(a) in controls from a healthy population, in genetically diagnosed heFH and mutation-negative hypercholesterolemia subjects, and to assess the influence on Lp(a) of the genetic defect responsible for heFH.

Source: Atherosclerosis - August 22, 2021 Category: Cardiology Authors: Victoria Marco-Bened í, Ana Cenarro, Martín Laclaustra, Asier Larrea-Sebal, Estíbaliz Jarauta, Itziar Lamiquiz-Moneo, Pilar Calmarza, Ana M. Bea, Núria Plana, Xavier Pintó, César Martín, Fernando Civeira Source Type: research