Impaired Mitochondrial Bioenergetics Function in Pediatric Chronic Overlapping Pain Conditions with Functional Gastrointestinal Disorders
CONCLUSION: Subjects with COPC have reduced mitochondrial capacity to produce ATP. Predisposing genetic factors or reversible acquired changes may be responsible. A higher SRC best predicts disability. Since a higher SRC is typically associated with more mitochondrial reserve, the SRC may indicate an underutilized available energy supply related to inactivity, or a "brake" on mitochondrial function. Prospective longitudinal studies can likely discern whether these findings represent deconditioning, true mitochondrial dysfunction, or both.PMID:34426756 | PMC:PMC8380178 | DOI:10.1155/2021/6627864
Source: Pain Research and Management - Category: Anesthesiology Authors: Gisela Chelimsky Pippa Simpson Liyun Zhang Doug Bierer Steve Komas Balaraman Kalyanaraman Thomas Chelimsky Source Type: research
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