Pulmonary vascular resistance predicts mortality in patients with pulmonary hypertension associated with interstitial lung disease: results from the COMPERA registry

Pulmonary hypertension (PH) is a common complication of many chronic lung diseases, especially COPD and interstitial lung disease (ILD) [1]. In these conditions, the development of PH is associated with an aggravation of symptoms and an increase in mortality risk. In most patients with chronic lung disease, the haemodynamic severity of PH is mild to moderate, while some patients develop severe PH, which is presently defined by a mean pulmonary arterial pressure (mPAP) ≥35 mmHg or mPAP ≥25 mmHg in the presence of a cardiac index <2.0 L·min–1·m–2 [2]. These haemodynamic criteria were introduced per expert consensus but were not based on solid data.

Source: European Respiratory Journal - August 26, 2021 Category: Respiratory Medicine Authors: Olsson, K. M., Hoeper, M. M., Pausch, C., Grünig, E., Huscher, D., Pittrow, D., Rosenkranz, S., Gall, H. Tags: Original Articles: Research letters Source Type: research